Bone and Cartilage

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, Volume 40, Issue 3, pp 215-219

Cartilage destruction and osteophytes in instability-induced murine osteoarthritis: Role of TGFβ in osteophyte formation?

  • Wim B. van den BergAffiliated withDepartment of Rheumatology, University Hospital Nijmegen
  • , Gerjo J. V. M. van OschAffiliated withDepartment of Rheumatology, University Hospital Nijmegen
  • , Peter M. van der KraanAffiliated withDepartment of Rheumatology, University Hospital Nijmegen
  • , Henk M. van BeuningenAffiliated withDepartment of Rheumatology, University Hospital Nijmegen

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Abstract

Osteoarthritis is characterized by focal cartilage destruction and marked formation of osteophytes. We have investigated the possible relationship between site specific occurrence of cartilage damage and osteophytes in the collagenase induced murine osteoarthritis model. The degree of instability of the joint correlated with the amount of cartilage loss. Moreover, cartilage damage in the medial tibial plateau correlated only strongly with the osteophyte at the medial plateau, whereas a similar, site directed trend was noted for lateral damage and lateral osteophytes. A separate study with intraarticular injection of TGFβ1 in normal murine knee joints revealed that this factor can induce osteophytes at characteristic sites, suggesting a role of endogenous TGFβ in this phenomenon.