Summary
An endogenous, heat-stable inhibitor of high mol. wt (approximately 3×105) was found to be present in rat brain, which inhibited Ca2+-dependent neutral protease specifically but not due to its binding of Ca2+ in the medium.
Similar content being viewed by others
References
G. Guroff, J. biol. Chem.239, 149 (1964).
I. Nishiura, H. Hanada and T. Murachi, Neurol. Med. Chir.19, 1 (1979).
M. Kunitz, J. gen. Physiol.30, 291 (1947).
G.I. Drummond and L. Duncan, J. biol. Chem.243, 5532 (1968).
L. Waxman and E.G. Krebs, J. biol. Chem.253, 5888 (1978).
I. Nishiura, K. Tanaka, S. Yamato and T. Murachi, J. Biochem. (Tokyo)84, 1657 (1978).
M. Inoue, A. Kishimoto, Y. Takai and Y. Nishizuka, J. biol. Chem.252, 7610 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nishiura, I., Tanaka, K. & Murachi, T. A high molecular weight inhibitor of Ca2+-dependent neutral protease in rat brain. Experientia 35, 1006–1007 (1979). https://doi.org/10.1007/BF01949908
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01949908