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Chromatographic evidence for the synthesis of possible sleep-mediators inTrypanosoma brucei gambiense

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Résumé

Les trypanosomes ont converti les substratsl-tryptophan etdl-5-hydroxytryptophan en métabolites tryptophol (indole-3-éthanol) et 5-hydroxytryptophol, deux composés qui produisent le sommeil chez la souris et le poussin. Les effets possibles de ces composés soporifiques chez un homme infecté par ce parasite et leur rôle dans le métabolisme du parasite, sont discutés.

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Authors and Affiliations

  1. Laboratory of Parasitology, Department of Biology, Tulane University, 70118, New Orleans, Louisiana, USA

    H. H. Stibbs & J. R. Seed

Authors
  1. H. H. Stibbs
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  2. J. R. Seed
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Supported in part by a Research Corporation grant from the Brown-Hazen fund.

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Stibbs, H.H., Seed, J.R. Chromatographic evidence for the synthesis of possible sleep-mediators inTrypanosoma brucei gambiense. Experientia 29, 1563–1565 (1973). https://doi.org/10.1007/BF01943919

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