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Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids fromTrypanosoma cruzi

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Summary

Epimastigotes ofTrypanosoma cruzi (Tulahuen strain Tul 0 stock) biotransform benznidazole (N-benzyl-2-nitro-1-imidazone acetamide) to reactive metabolites that bind covalently to DNA, proteins and lipids of the parasite. These effects might be related to the trypanocidal action of benznidazole, a chemotherapeutic agent against Chagas' disease.

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Authors and Affiliations

  1. Centro de Investigaciones Toxicológicas (CEITOX), CITEFA/CONICET, Zufriategui 4380, 1603, Villa Martelli, Pcia de Buenos Aires, Argentina

    E. G. Díaz de Toranzo & J. A. Castro

  2. Instituto de Investigaciones Bioquímicas Fundción Campomar, Antonio Machado 151, 1405, Buenos Aires, Argentina

    B. M. Franke de Cazzulo & J. J. Cazzulo

Authors
  1. E. G. Díaz de Toranzo
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  2. J. A. Castro
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  3. B. M. Franke de Cazzulo
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  4. J. J. Cazzulo
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Díaz de Toranzo, E.G., Castro, J.A., Franke de Cazzulo, B.M. et al. Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids fromTrypanosoma cruzi. Experientia 44, 880–881 (1988). https://doi.org/10.1007/BF01941187

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  • DOI: https://doi.org/10.1007/BF01941187

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