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On the effect of amantadine on monoamines and their metabolites in the brain and cerebrospinal fluid

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Zusammenfassung

Nachweis des stark herabgesetzten Säuregehalts der Homovanillinsäure und der 5-Hydroxy-indolessigsäure im Liquor cerebrospinalis von Parkinsonkranken im Vergleich mit normalen Versuchspersonen. Die Amantadin-Therapie hingegen ergab keine bedeutenden veränderungen und der Gehalt von Dopamin, Noradrenalin und Homovanillinsäure im Gehirn der behandelten Parkinsonpatienten entsprach auch den Werten der übrigen Parkinsonkranken. Ausserdem hatte Amantadin keinen Einfluss auf den endogenen Gehalt dieser Amine im Rattengehirn.

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Authors and Affiliations

  1. Department of Neurology, University of Turku, SF-20520, Turku 52, Finland

    U. K. Rinne, V. Sonninen & M. Hyyppä

Authors
  1. U. K. Rinne
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  2. V. Sonninen
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  3. M. Hyyppä
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Supported by a grant from the National Research Council for Medical Sciences (Finland).

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Rinne, U.K., Sonninen, V. & Hyyppä, M. On the effect of amantadine on monoamines and their metabolites in the brain and cerebrospinal fluid. Experientia 28, 57–59 (1972). https://doi.org/10.1007/BF01928264

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