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The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide

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Summary

Both the original and the synthetic nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu enhance, in recipient rabbits, spindle and delta EEG activity as in orthodox slow wave sleep.

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References

  1. M. Monnier, Th. Koller and S. Graber, Exp. Neurol.8, 264 (1963).

    Article  Google Scholar 

  2. M. Monnier and L. Hösli, Science146, 796 (1964).

    Article  CAS  PubMed  Google Scholar 

  3. M. Monnier and L. Hösli, Pflügers Arch.282, 60–75, 1965.

    Article  CAS  Google Scholar 

  4. M. Monnier and A. M. Hatt, Pflügers Arch.317, 268 (1970).

    Article  CAS  PubMed  Google Scholar 

  5. M. Monnier, A. M. Hatt, L. B. Cueni and G. A. Schoenenberger, Pflügers Arch.331, 257 (1972).

    Article  CAS  PubMed  Google Scholar 

  6. M. Monnier, L. Dudler and G. A. Schoenenberger, Pflügers Arch.345, 23 (1973).

    Article  CAS  PubMed  Google Scholar 

  7. G. A. Schoenenberger and M. Monnier, in: Brain and Sleep, p. 36. De Erven Bohn BV, Amsterdam 1974.

    Google Scholar 

  8. G. A. Schoenenberger and M. Monnier, in: Sleep. 2nd Eur. Congr. Sleep Res., Rome 1974, p. 46. Karger, Basel 1975.

    Google Scholar 

  9. M. Monnier, G. A. Schoenenberger, L. Dudler and B. Herkert, in: Sleep. 2nd Eur. Congr. Sleep Res., Rome 1974, p. 41. Karger, Basel 1975.

    Google Scholar 

  10. R. Edvinsson, R. Hakanson and F. Sundler, Analyt. Biochem.46, 473 (1972).

    Article  CAS  PubMed  Google Scholar 

  11. W. R. Gray, in: Methods in Enzymology. Dansyl chloride procedure, vol. XI, p. 139. Ed. H. W. Hirs, S. P. Colwick and N. O. Kaplan. Academic Press, New York and London 1967.

    Google Scholar 

  12. M. Monnier and A. M. Hatt, Pflügers Arch.329, 231 (1971).

    Article  CAS  PubMed  Google Scholar 

  13. M. Monnier, A. M. Hatt, L. Dudler, L. B. Cueni and G. A. Schoenenberger, Ist Eur. Congr. Sleep Res., Basel 1972, p. 258. Karger, Basel 1973.

    Google Scholar 

  14. V. M. Monnier, Synthesis of the Tripeptide L-Trp-L-Ser-L-Glu. Comparison of the biological activity with that of the deltasleep inducing peptide DSIP. Experientia Suppl. 29. Birkhäuser, Basel 1977.

  15. M. Monnier and G. A. Schoenenberger, 3rd Eur. Congr. Sleep Res., Montpellier, 7 September 1976.

  16. B. S. Hartley, Biochem. J.51, 441 (1970).

    Google Scholar 

  17. J. R. Pappenheimer, G. Koski, V. Fencl, M. L. Karnovski and J. Krueger, J. Neurophysiol.38, 1299 (1975).

    Article  CAS  PubMed  Google Scholar 

  18. H. Nagasaki, M. Iriki, S. Inoué, K. Uchizono, Proc. Jap. Acad.50, 241 (1974).

    Article  Google Scholar 

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Author notes

  1. M. Monnier

    Present address: Physiological Institute, University of Basel, Vesalgasse 1, CH-4051, Basel, Switzerland

  2. G. A. Schoenenberger

    Present address: Research Division, Department of Surgery, Kantonsspital Basel, CH-4031, Basel, Switzerland

Authors and Affiliations

  1. Physiological Institute, University of Basel, Vesalgasse 1, CH-4051, Basel, Switzerland

    L. Dudler, R. Gächter, P. F. Maier, H. J. Tobler & G. A. Schoenenberger

  2. Research Division, Department of Surgery, Kantonsspital Basel, CH-4031, Basel, Switzerland

    M. Monnier, L. Dudler, R. Gächter, P. F. Maier & H. J. Tobler

Authors
  1. M. Monnier
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  2. L. Dudler
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  3. R. Gächter
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  4. P. F. Maier
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  5. H. J. Tobler
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  6. G. A. Schoenenberger
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Additional information

Acknowledgment. This work was supported by grants from the Swiss National Foundation for Scientific Research (No. 3.871.72, 3.527.75,3.443.074, 3.780.076), Fonds für Lehre und Forschung der Universität Basel, Merck Sharp and Dohme (USA), Ciba-Stiftung Basel, Hoffmann La Roche Ltd Basel, Sandoz Ltd Basel. We received valuable help from Dr S. Roncari, Dr B. Wilson and Dr C. D. Bennett for chemical research, and from Prof. A. Cerletti, Dr H. J. Tobler and Mr J. J. Regez (Division of Application and Research Development, Sandoz Ltd) for data processing.

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Monnier, M., Dudler, L., Gächter, R. et al. The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide. Experientia 33, 548–552 (1977). https://doi.org/10.1007/BF01922266

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  • DOI: https://doi.org/10.1007/BF01922266

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