Skip to main content
SpringerLink
Log in

Induction of rotational behaviour by intranigral baclofen suggests possible GABA-agonist activity

  • Pharmacologica
  • Published:
Experientia Aims and scope Submit manuscript

Summary

In rats, unilateral injections of the GABA-derivative baclofen into the zona reticulata of the substantia nigra produced a contralateral rotation that was translated to ipsilateral rotation under the influence of amphetamine. These results mimic those following unilateral elevation of GABA levels in the substantia nigra and suggest that baclofen may have some GABA agonist activity following intracerebral injection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. K. Fuxe, A. Ljungdahl, L. Agnati, O. Johansson and M. Perez de la Mora, Med. Biol.53, 177 (1975).

    CAS  PubMed  Google Scholar 

  2. S. R. Naik, A. Guidotti and E. Costa, Neuropharmacology15, 479 (1976).

    Article  CAS  PubMed  Google Scholar 

  3. D. R. Curtis, C. J. A. Game, G. A. R. Johnston and R. M. McCulloch, Brain Res.70, 493 (1974).

    Article  CAS  PubMed  Google Scholar 

  4. J. Davies and J. C. Watkins, Brain Res.70, 501 (1974).

    Article  CAS  PubMed  Google Scholar 

  5. E. Puil, K. Krnjevic and R. Werman, Proc. Can. Fed. biol. Soc.19, 20 (1976).

    Google Scholar 

  6. S. D. Glick, T. P. Jerussi and L. N. Fleisher, Life Sci.18, 889 (1976).

    Article  CAS  PubMed  Google Scholar 

  7. A. Dray, N. R. Oakley and M. A. Simmonds, J. Pharm. Pharmac.27, 627, (1975).

    Article  CAS  Google Scholar 

  8. G. Koob, M. Del Fiacco and S. D. Iversen, Br. J. Pharmac.58, 454P (1976).

  9. A. Dray and D. W. Straughan, J. Pharm. Pharmac.28, 400 (1976).

    Article  CAS  Google Scholar 

  10. J. F. R. König and R. A. Klippel, The rat brain: a stereotaxic atlas of the forebrain. Williams and Wilkins, Baltimore 1963.

    Google Scholar 

  11. K. Saito, S. Konishi and M. Otsuka, Brain Res.97, 177 (1975).

    Article  CAS  PubMed  Google Scholar 

  12. K. J. Fotherby, N. J. Morrish and R. W. Ryall, Brain Res.113, 210 (1976).

    Article  CAS  PubMed  Google Scholar 

  13. J. L. Henry and Y. Ben-ari, Brain Res.117, 540 (1976).

    Article  CAS  PubMed  Google Scholar 

  14. I. Kanazawa, P. C. Emson and A. Cuello, Brain Res.119, 447 (1977).

    Article  CAS  PubMed  Google Scholar 

  15. I. Kääriäinen, Acta pharmac. tox.39, 393 (1976).

    Article  Google Scholar 

  16. S. Korsgaard, Acta psychiat. scand.54, 17 (1976).

    Article  CAS  PubMed  Google Scholar 

  17. I. Kääriänen and P. Vikberg, Acta pharmac. tox.39, 536 (1976).

    Article  Google Scholar 

  18. M. Linnoila, M. Viukari and O. Heitala, Br. J. Psychiat.129 114 (1976).

    Article  CAS  Google Scholar 

  19. P. Bernard, S. J. Edwards, S. Fielding, R. D. Robson, J. K. Saelens, J. P. Simke and J. Welch, Pharmacologist17, 256 (1975).

    Google Scholar 

  20. P. Soubrie, P. Simon and J. J. R. Boissier, Experientia32, 1323 (1976).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Psychiatry, MRC Clinical Research Centre, HA1 3UJ, Harrow, Middleses, England

    J. L. Waddington

Authors
  1. J. L. Waddington
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Baclofen was a generous gift of Ciba-Geigy Ltd.

J. L. W. is a Medical Research Council Scholar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Waddington, J.L. Induction of rotational behaviour by intranigral baclofen suggests possible GABA-agonist activity. Experientia 33, 1345–1346 (1977). https://doi.org/10.1007/BF01920172

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01920172

Keywords

Search

Navigation