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Effect of insulin on immunological phagocytosis by macrophages

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Summary

It was shown that, in physiological concentrations, insulin enhances, in vitro, the immunological phagocytosis of sensitized sheep erythrocytes by cultured mouse peritoneal macrophages. Insulin seems to stimulate macrophage phagocytosis as a cholinomimetic agonist by increasing the intracellular levels of cyclic GMP.

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Authors and Affiliations

  1. Centro de pesquisas Arlindo de Assis (FAP), Av. Almirante Barroso 54, Rio de Janeiro, (Brazil)

    A. Oliveira Lima, M. Queiroz, H. M. Bräscher & J. Vargens

  2. Instituto de Puericultura e Pediatria, U.F.R.J., Rio de Janeiro, (Brazil)

    A. Oliveira Lima, M. Queiroz, H. M. Bräscher & J. Vargens

Authors
  1. A. Oliveira Lima
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  2. M. Queiroz
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  3. H. M. Bräscher
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  4. J. Vargens
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Additional information

Acknowledgments. This investigation was supported by a grant from the National Council for Cientific and Tecnological Development (CNPq), Rio de Janeiro, Brazil.

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Lima, A.O., Queiroz, M., Bräscher, H.M. et al. Effect of insulin on immunological phagocytosis by macrophages. Experientia 35, 119–120 (1979). https://doi.org/10.1007/BF01917915

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  • DOI: https://doi.org/10.1007/BF01917915

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