Summary
The family trees of 142 patients, suffering from histologically proven brain tumour, were compared to those of an equal number of sex and age matched controls. The results showed no statistically significant differences in the occurrence of malignant neoplasm between the two groups. These results indicate that the risk of cancer among relatives of patients with brain tumours does not exceed that of healthy controls.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Armstrong RM, Hanson CW (1969) Familial gliomas. Neurology 19: 1061–1063
Bellur SN, Chandra V, McDonald LW (1979) Association of meningiomas with extraneural primary malignancies. Neurology 29: 1165–1168
Challa VR, Goodman HO, Daris CH (1983) Familial brain tumours: Studies of two families and review of the recent literature. Neurology 12: 18–23
Delleman JW, De Jong JGY, Bleeker GM (1978) Meningiomas in five members of a family over two generations, in one member simultaneously with acoustic neurinomas. Neurology 28: 567–570
Draper GJ, Heaf MM; Kinnier Wilson LM (1977) Occurrence of childhood cancers among sibs and estimation of familial risks. J Med Genet 14: 81–90
Hartley AL, Birch JM, Marsden HB, Reid H, Harris M, Blair V (1987) Adrenal cortical tumors: epidemiological and familial aspects. Arch Dis Child 62: 683–689
Kitchin FD, Ellsworth RM (1974) Pleiotropic effects of the gene for retinoblastoma. J Med Genet 11: 244–246
Knudson AJ (1986) Genetics of human cancer. Ann Rev Genet 20: 231–252
Meadows AT, D'Angio GJ, Mike V, Banfi A, Harris C, Jenkins RDT, Schwartz A (1977) Patterns of second malignant neoplasms in children. Cancer 40: 1901–1911
Pelgrom von Motz IJ, Bots AM, Endtz LJ (1977) Astrocytoma in three sisters. Neurology 27: 1038–1041
Schimke RN (1990) Cancer genetics. In: Emery AEH, Rimoin DL (eds) Principle and practice of medical genetics. Churchill Livingstone, Edinburgh, pp1881–1908
Schoenberg BS, Christine BW, Whisnant JP (1975) Nervous system neoplasms and primary malignancies in other sites. Neurology 25: 705–712
Schoenberg BS, Gista GG, Reagan TJ (1975) The familial occurrence of glioma. Surg Neurol 3: 139–145
Schoenberg BS (1991) Epidemiology of primary intracranial neoplasms. Disease distribution and risk factors. In: Salcman M (ed) Neurobiology of brain tumors. Williams and Wilkins, Baltimore, pp3–18
Slowik E, Jellinger K (1990) Association of primary cerebral lymphoma with meningioma: report of two cases. Clin Neuropath 9: 69–73
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sakas, D., Kalfakis, N., Panas, M. et al. The risk of cancer in relatives of patients with brain neoplasm. Acta neurochir 131, 226–228 (1994). https://doi.org/10.1007/BF01808618
Issue Date:
DOI: https://doi.org/10.1007/BF01808618