Skip to main content
Log in

Interrupted pregnancy as an indicator of poor prognosis in T1, 2, N0, M0 primary breast cancer

  • Report
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Summary

We examined the records of women with primary breast cancer for a history of pregnancy and live births. The patients were all histopathologic T1, 2, N0, M0 white females, untreated post modified radical mastectomy. Patients with a history of interrupted pregnancies have a significantly shorter time to recurrence than those with normal pregnancy history. A trend toward a lower incidence of highly differentiated histological pattern is also observed in cancers from these patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Rich MA, Brennan MJ, and the Scientific, Pathology and Surgical Associates of the MCF Breast Cancer Prognostic Study: The Breast Cancer Prognostic Program: A study of the metastatic process.In MJ Brennan et al. (ed). New Concepts in Etiology and Control. Academic Press, New York, 1980, pp 29–51

    Google Scholar 

  2. Fisher B, Slack NH, Bross IDJ, and Cooperating Investigators: Cancer of the breast: size of neoplasm and prognosis. Cancer 24:1071–1080, 1969

    Article  PubMed  CAS  Google Scholar 

  3. Friedell GH, Goldenberg IS, Masnyk IH, McMahan CA, Ravdin RG, Roberts JB, Segaloff A, Welsch F: Identification of breast cancer patients with high risk of early recurrence after radical mastectomy. I. Description of study. J Natl Cancer Inst 53:603–607, 1974

    PubMed  CAS  Google Scholar 

  4. American Joint Committee for Cancer Staging and End-Results Reporting: Manual for Staging of Cancer, 1978

  5. Foote FW Jr, Stewart FW: Histologic classification of carcinoma of the breast. Surgery 19:74, 1946

    Google Scholar 

  6. Gross AJ, Clark VA: Survival distributions: reliability applications in the biomedical sciences. John Wiley and Sons, New York, 1975, p 31

    Google Scholar 

  7. Breslow N: A generalized Kruskal-Wallis test for comparing K samples subject to unequal patterns of censorship. Biometrika 57:579–594, 1970

    Article  Google Scholar 

  8. Cox DR: Regression models and life tables. J R Stat Soc Series B. 34:187–220, 1972

    Google Scholar 

  9. Kalbfleisch JD, Prentice RL: The statistical analysis of failure time data. John Wiley and Sons, New York, 1980, pp 70–118

    Google Scholar 

  10. Fox DJ, Guire KE: Documentation for MIDAS. 3rd ed. Statistical Research Laboratory, University of Michigan, Ann Arbor, 1976

    Google Scholar 

  11. Brennan MJ, Russo J, Brooks S, Ownby H, Roi L, and the Breast Cancer Prognostic Study Associates: Identification of a subset of T1, 2, N0 primary breast cancer patients with poor prognosis (abstract). Breast Cancer Res Treat 2:280, 1982

    Google Scholar 

  12. Choi NW, Howe GR, Miller AB, Matthews V, Morgan RW, Munan L, Burch JD, Feather J, Jain M, Kelly A: An epidemiologic study of breast cancer. Am J Epidemiol 107:501–521, 1978

    Google Scholar 

  13. Pike MC, Henderson BE, Casagrande TJ, Rosario I, Gray GE: Oral contraceptive use and early abortion as risk factors for breast cancer in young women. Br J Cancer 53:72–76, 1981

    Google Scholar 

  14. Valoras VG, MacMahon B, Trichopoulos D, Polychronopoulou A: Lactation and reproductive histories of breast cancer patients in greater Athens, 1965–67. Int J Cancer 4:350–363, 1969

    Google Scholar 

  15. Lim TM, Chen KP, MacMahon B: Epidemiologic characteristics of cancer of the breast in Taiwan. Cancer 27:1497–1504, 1971

    Article  Google Scholar 

  16. Mirra AP, Cole P, MacMahon B: Breast cancer in an area of high parity. Sao Paulo, Brazil. Cancer Res 31:77–83, 1971

    PubMed  CAS  Google Scholar 

  17. Ravnihar B, MacMahon B, Lindtner J: Epidemiologic features of breast cancer in Slovenia, 1965–67. Eur J Cancer 7:295–306, 1971

    PubMed  CAS  Google Scholar 

  18. Glass RH, Golbus MS: Habitual abortion. Fertil Steril 29:257–265, 1980

    Google Scholar 

  19. Tho PT, Byrd JR, McDonough PG: Etiologies and subsequent reproductive performance of 100 couples with recurrent abortion. Fertil Steril 32:389–395, 1979

    Google Scholar 

  20. Grattarola R: The premenstrual endometrial pattern of women with breast cancer. Cancer 17:1119–1122, 1964

    Article  PubMed  CAS  Google Scholar 

  21. Papatestas AE, Mulvihill M, Josi C, Ioannovich J, Lesnick G, Aufses AH: Parity and prognosis in breast cancer. Cancer 45:191–194, 1980

    Article  PubMed  CAS  Google Scholar 

  22. Mauvais-Jarvis P, Sitruk-Ware R, Kuttenn F, Sterkers N: Luteal phase insufficiency: A common pathophysiologic factor in development of benign and malignant breast diseases.In RD Bulbrook and DJ Taylor (eds): Commentaries on Research in Breast Disease. Alan Liss, New York, 1979, pp 25–29

    Google Scholar 

  23. Russo J, Tay LK, Russo IH: Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res Treat 2:5–73, 1982

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Consortia

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ownby, H.E., Martino, S., Roi, L.D. et al. Interrupted pregnancy as an indicator of poor prognosis in T1, 2, N0, M0 primary breast cancer. Breast Cancer Res Tr 3, 339–344 (1983). https://doi.org/10.1007/BF01807586

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01807586

Keywords

Navigation