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The uptake and extrusion of monovalent cations by isolated heart mitochondria

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Summary

The factors involved in the movement of monovalent cations across the inner membrane of the isolated heart mitochondrion are reviewed. The evidence suggests that the energy-dependent uptake of K+ and Na+ which results in swelling of the matrix is an electrophoretic response to a negative internal potential. There are no clear cut indications that this electrophoretic cation movement is carrier-mediated and possible modes of entry which do not require a carrier are examined. The evidence also suggests that the monovalent cation for proton exchanger (Na+ > K+) present in the membrane may participate in the energy-dependent extrusion of accumulated ions. The two processes, electrophoretic cation uptake (swelling) and exchange-dependent cation extrusion (contraction) may represent a means of controlling the volume of the mitochondrion within the functioning cell. A number of indications point to the possibility that the volume control process may be mediated by the divalent cations Ca+2 and Mg+2. Studies with mercurial reagents also implicate certain membrane thiol groups in the postulated volume control process.

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  1. Department of Physiological Chemistry, College of Medicine, Ohio State University, 43210, Columbus, Ohio, USA

    Gerald P. Brierley

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Brierley, G.P. The uptake and extrusion of monovalent cations by isolated heart mitochondria. Mol Cell Biochem 10, 41–62 (1976). https://doi.org/10.1007/BF01731680

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  • DOI: https://doi.org/10.1007/BF01731680

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