Summary
A patient with chronic idiopathic neutropenia, who had been suffering from repeated infections, was successfully treated with recombinant granulocyte stimulating factor (rhG-CSF). Subcutaneous injection of 30μg/m2 rhG-CSF every two days was sufficient to maintain the neutrophil count at approximately 1,000/μl. The patient has lived without any evidence of infection for the last 10 months using that treatment. There were no side effect caused by rhG-CSF and antibodies against G-CSF were not detected in the patient's plasma.
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Furukawa, T., Takahashi, M., Moriyama, Y. et al. Successful treatment of chronic idiopathic neutropenia using recombinant granulocyte colony-stimulating factor. Ann Hematol 62, 22–24 (1991). https://doi.org/10.1007/BF01714979
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DOI: https://doi.org/10.1007/BF01714979