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Mucormycosis in the immunocompromised host

Mucormykose bei infektabwehrgeschwächten Patienten

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Summary

We are presenting two typical case histories of mucormycosis in patients with acute leukaemia which illustrate some of the important features of this infection in compromised hosts. In such patients, mucormycosis is mostly pulmonary or widely disseminated and often has a rapidly fatal course. A microbiological diagnosis from blood or sputum is difficult to establish. Mucormycosis or other fungal infections should be suspected in compromised patients with infections which do not respond to adequate antibiotic therapy.

Zusammenfassung

An zwei Kasuistiken von Mucormykose bei Patienten mit akuten Leukämien werden die typischen Symptome und Verläufe dieser Infektion bei infektabwehrgeschwächten Patienten dargestellt. Bei diesen Patienten tritt vorwiegend die pulmonale oder disseminierte Form der Mucormykose auf, die meist rasch tödlich verläuft. Die Diagnose ist schwierig, da ein mikrobiologischer Nachweis aus Sputum oder Blut nur selten gelingt. Der Verdacht auf das Vorliegen einer Mucormykose oder einer anderen Pilzinfektion sollte insbesondere dann aufkommen, wenn bei einem Patienten mit einer Abwehrschwäche eine Infektion auf eine adäquate antibiotische Therapie nicht anspricht.

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Literature

  1. Lehrer, R. I., Howard, D. H., Sypherd, P. S., Edwards, J. E., Segal, G. P., Winston, D. J. Mucormycosis. Ann. Intern. Med. 93 (1980) 93–108.

    Article  Google Scholar 

  2. Meyer, R. D., Armstrong, D. Mucormycosis-changing status. Crit. Rev. Clin. Lab. Sci. 4 (1973) 421–450.

    Article  CAS  Google Scholar 

  3. Armstrong, D. Fungal infections in the compromised host. In:Rubin, R. H., Young, L. S. (eds.): Clinical approach to infection in the compromised host. Plenum Medical Book Company, New York 1981, pp. 195–228.

    Google Scholar 

  4. Krick, J. A., Remington, J. S. Opportunistic invasive fungal infections in patients with leukaemia and lymphoma. Clin. Haematol. 5 (1976) 249–310.

    PubMed  CAS  Google Scholar 

  5. Rosen, P. P. Opportunistic fungal infections in patients with neoplastic diseases. Pathol. Ann. 11 (1976) 255–314.

    CAS  Google Scholar 

  6. Marchevsky, A. M., Bottone, E. J., Geller, S. A., Giger, D. K. The changing spectrum of disease, etiology and diagnosis of mucormycosis. Hum. Pathol. 11 (1980) 457–464.

    Article  CAS  PubMed  Google Scholar 

  7. Meyer, R. D., Rosen, P., Armstrong, D. Phycomycosis complicating leukemia and lymphoma. Ann. Intern. Med. 77 (1972) 871–879.

    Article  CAS  PubMed  Google Scholar 

  8. Medoff, G., Kobayashi, G. S. Pulmonary mucormycosis. N. Engl. J. Med. 286 (1972) 86–87.

    Article  CAS  PubMed  Google Scholar 

  9. Baker, R. D. Mucormycosis — a new disease? JAMA 163 (1957) 805–808.

    Article  CAS  Google Scholar 

  10. Commers, J. R., Pizzo, P. A. The role of empirical antifungal therapy for granulocytopenic cancer patients with persistent fever. In:Klastersky, J. (ed.): Infections in cancer patients. Raven Press, New York 1982, pp. 157–170.

    Google Scholar 

  11. Van Cutsem, J. Untersuchungen zur antimykotischen Aktivität von Ketoconazolin vitro undin vivo. In:Seeliger, H. P. R., Hauck, H. (eds.): Chemotherapie von Oberflächen-, Organ- und Systemmykosen. Perimed, Erlangen 1982, pp. 21–24.

    Google Scholar 

  12. Eden, O. B., Santos, J. Effective treatment of rhinopulmonary mucormycosis in a boy with leukaemia. Arch. Dis. Child. 54 (1979) 557–559.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Bhaduri, S., Kurrle, E., Vanek, E. et al. Mucormycosis in the immunocompromised host. Infection 11, 170–172 (1983). https://doi.org/10.1007/BF01641299

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  • DOI: https://doi.org/10.1007/BF01641299

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