Abstract
Granulocyte-colony stimulating factor (G-CSF) is a member of colony stimulating factors which regulate the proliferation and differentiation of hematopoietic progenitor cells. A full-length cDNA clone coding human G-CSF was used as a hybridization probe to detect homologous sequence in human-mouse somatic cell hybrids, flow-sorted human chromosomes, and in situ human metaphase chromosomes. The results indicate that the gene encoding human G-CSF is on the q21–q22 region of chromosome 17, which is involved in translocation of t(15;17) (q23;21) in human acutepromyelocytic leukemia.
Literature cited
Metcalf, D. (1985).Science 229:16–22.
Metcalf, D. (1986).Blood 67:257–267.
Huebner, K., Isobe, M., Croce, C.M., Golde, D.W., Kaufman, S.E., and Gasson, J.C. (1985).Science 230:1282–1285.
Le Beau, M.M., Westbrook, C.A., Diaz, M.O., Larson, R.A., Rowley, J.D., Gasson, J.C., Golde, D.W., and Sherr, C.J. (1986).Science 231:981–987.
Larson, R.A., Kondo, K., Vardiman, J.W., Butler, A.E., Golombo, H.M., and Rowley, J.D. (1984).Am. J. Med. 76:827–841.
Nagata, S., Tsuchiya, M., Asano, S., Kaziro, Y., Yamazaki, T., Yamamoto, O., Hirata, Y., Kubota, N., Oheda, M., Nomura, H., and Ono, M. (1986).Nature 319:415–418.
Maniatis, T., Fritsch, E.F., and Sambrook, J. (1982).Molecular Cloning, A Laboratory Manual (Cold Spring Harbor Laboratory, New York).
Semba, K., Yamanashi, Y., Nishizawa, M., Sukegawa, J., Yoshida, M., Sasaki, M., Yamamoto, T., and Toyoshima, K. (1985).Science 227:1038–1040.
Yoshida, M.C., Ikeuchi, T., and Sasaki, M. (1975).Proc. Jpn. Acad. 51:184–187.
Testa, J.R., Rowley, J.D., Hawkins, C., Yu, R.L., Aronson, M.M., Mulivor, R.A., Greene, A.E., and Coriell, L.L. (1980).Cytogenet. Cell Genet. 27:270.
Sillar, R., and Young, B.D. (1981).J. Histochem. Cytochem. 29:74–78.
Fukushige, S.-I., Murotsu, T., and Matsubara, K.-I. (1986).Biochem. Biophys. Res. Commun. 134:477–483.
Kanda, N., Schreck, R., Alt, F., Bruns, G., Baltimore, D., and Latt, S. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:4069–4073.
Nagata, S., Tsuchiya, M., Asano, S., Yamamoto, O., Hirata, Y., Kubota, N., Oheda, M., Nomura, H., and Yamazaki, T. (1986).EMBO J. 5:575–581.
Tsuchiya, M., Kaziro, Y., and Nagata, S. (1987).Eur. J. Biochem. 165:7–12.
Fukushige, S.-I., Matsubara, K.-I., Yoshida, M., Sasaki, M., Suzuki, T., Semba, K., Toyoshima, K., and Yamamoto, T. (1986).Mol. Cell. Biol. 6:955–958.
Dayton, A.I., Selden, J.R., Laws, G., Dorney, D.J., Finan, J., Tripputi, P., Emanuel, B.S., Rovera, G., and Nowell, P.C. (1984).Proc. Natl. Acad. Sci. U.S.A. 81:4495–4499.
Huebner, K., Isobe, M., Chao, M., Rothwell, M., Ross, A.H., Finan, J., Hoxie, J.A., Sehgal, A., Buck, C.R., Lanahan, A., Nowell, P.C., Koprowski, H., and Croce, C.M. (1986).Proc. Natl. Acad. Sci. U.S.A. 83:1403–1407.
Barlow, D.P., Bucan, M., Lehrach, H., Hogan, B.L.M., Gough, N.M. (1987).EMBO J. 6:617–623.
Lalley, P.A., and McKusick, U.A. (1985).Cytogenet. Cell Genet. 40:536–566.
Tsuchiya, M., Asano, S., Kaziro, Y., and Nagata, S. (1986).Proc. Natl. Acad. Sci. U.S.A. 83:7633–7637.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kanda, N., Fukushige, Si., Murotsu, T. et al. Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17. Somat Cell Mol Genet 13, 679–684 (1987). https://doi.org/10.1007/BF01534488
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01534488