Abstract
The pharmacokinetics of Tl+ were studied in 9 patients who underwent myocardial scintigraphy with201Tl+. The time course of the201Tl+ concentration fitted to an open two-compartment model. The following values were calculated:k 12=0.164±0.025 min−1,k 21=0.011 ± 0.004 min−1,k 10=0.005±0.004 min−1,t 1/2(κ1)=3.92±0.54 min, t1/2(λ2)= 3108±896 min,CL=0.08±0.03 l/min,V 1=0.26±0.13 I/kg,V z =4.36 ± 0.65 l/kg,V ss =4.23±0.67 l/kg. Using previously published dialysance values the influence of hemodialysis on Tl+ elimination was calculated. Hemodialysis in Tl+ intoxications should be moderately effective.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Atkins HL, Budinger TF, Lebwitz E, Ansari AN, Greene MW, Fairchild RG, Ellis KJ (1977) Thallium 201 for medical use, human distribution and physical imaging properties. J Nucl Med 18: 133–140
Barckow J, Jenss H (1976) Thalliumvergiftung. Med Klin 71: 1377–1382
Brittinger WD, Strauch M, Schwarzbeck A, Huber W, Henning GE v., Wilk G, Haag T (1970) Erfolgreiche Hämodialysebehandlung einer schweren Thalliumintoxikation. Therapiewoche 7: 288–290
Drasch G, Hauck G (1977) Verlaufskontrolle der Intensivtherapie von Thalliumintoxikationen. Arch Toxicol 38: 209–215
Henning CH, Forth W (1982) The excretion of thallium (I)-ions into the gastrointestinal tract in situ of rats. Arch Toxicol 49: 149–258
Hologgitas J, Ullucci P, Driscoll J (1980) Thallium elimination kinetics in acute thallotoxicosis. J Anal Toxicol 4: 68–73
Jax W, Grabensee B, Schröder E (1973) Die Therapie der Thalliumvergiftung. Med Welt 24: 691–693
Klotz U (1979) Klinische Pharmakologie. Fischer, Stuttgart New York
Loew H, Tillmann P, Winter R, Wießmann B, Koch R, Schiller M (1972) Thallium-Elimination durch die Hämodialyse im Vergleich zur großen Diurese bei einer schweren Thallium-Intoxikation. Med Welt 23: 1411–1412
Lund A (1956) Distribution of thallium in the organism and its elimination. Acta Pharmacol Toxicol 12: 251–259
Metzler CM, Elfring GL, McEwen AJ (1974) A package of computer programs for pharmacokinetic modeling. Biometrics 30: No 3
Paulson G, Vergara G, Young J, Bird M (1972) Thallium intoxication treated with dithizone and hemodialysis. Arch Intern Med 129: 100–103
Piazolo P, Franz HE, Brech W, Walb D, Wilk G (1971) Behandlung der Thalliumvergiftung mit der Hämodialyse. Dtsch Med Wochenschr 29: 1217–1222
Powell MJD (1965) A method for minimizing a sum of squares of non-linear functions without calculating derivatives. Comput J 7: 303–307
Rowland M, Tucker G (1980) Symbols in pharmacokinetics. J Pharmacokin Biopharmaceut 8: 497–507
Smith Pedersen R, Olesen AS, Freund LG, Solgaard P, Larsen E (1978) Thallium intoxication treated with long-term hemodialysis, forced diuresis and prussian blue. Acta Med Scand 204: 429–432
Strauss HW, Pitt B (1977) Thallium as a myocardial imaging agent. Semin Nucl Med 7: 49–58
Wackers FJ Th (1980) Thallium-201 myocardial scintigraphy in acute myocardial infarction. Semin Nucl Med 10: 127–145
Wagner JG (1975) Fundamentals of clinical pharmacokinetics. Drug Intelligence Publ., Hamilton
Author information
Authors and Affiliations
Additional information
The results are part of the MD Thesis of A. Talas
Rights and permissions
About this article
Cite this article
Talas, A., Pretschner, D.P. & Wellhöner, H.H. Pharmacokinetic parameters for thallium (I)-ions in man. Arch Toxicol 53, 1–7 (1983). https://doi.org/10.1007/BF01459996
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01459996