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Persistent reactivable latent herpes simplex virus infection in trigeminal ganglia of mice treated with antiviral drugs

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Summary

Latent reactivable infection was established with HSV in mouse trigeminal ganglion. A number of antiviral drugs (IUDR, acycloguanosine, Ara-A, PAA and PFA), effective against acute CNS infection with HSV, failed to influence the latent infection once established. Neither lipophilic properties of PFA-derivatives nor the combination of Ara-A and acyloguanosine improved the drug-effects on HSV latency.

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Authors and Affiliations

  1. Department of Virology, Institute of Medical Microbiology, University of Göteborg, Sweden

    B. Svennerholm, A. Vahlne & E. Lycke

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  1. B. Svennerholm
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  2. A. Vahlne
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  3. E. Lycke
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Svennerholm, B., Vahlne, A. & Lycke, E. Persistent reactivable latent herpes simplex virus infection in trigeminal ganglia of mice treated with antiviral drugs. Archives of Virology 69, 43–48 (1981). https://doi.org/10.1007/BF01315264

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  • DOI: https://doi.org/10.1007/BF01315264

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