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Effect of repeated administration of novel stressors on central beta adrenoceptors

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Summary

Subtypes of beta adrenoceptors were measured in 17 different areas of brain in rats exposed for 12 days to novel Stressors. Mild stress such as individual housing and handling caused no change in beta1 and beta2 adrenoceptors in comparison with that measured in rats that were group housed and never handled. Exposure of rats to more severe Stressors did reduce significantly the binding of125I-iodopindolol (125I-IPIN) to beta1 adrenoceptors, but not beta2 adrenoceptors, only in the lateral and basolateral nuclei of the amygdala.

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Author notes

  1. M. P. Areso

    Present address: Neuropsychopharmacology Unit, Departments of Veterans Affairs Medical Center, Philadelphia, PA, USA

Authors and Affiliations

  1. Departments of Pharmacology and Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    A. Frazer

Authors
  1. M. P. Areso
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  2. A. Frazer
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Areso, M.P., Frazer, A. Effect of repeated administration of novel stressors on central beta adrenoceptors. J. Neural Transmission 86, 229–235 (1991). https://doi.org/10.1007/BF01250709

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  • DOI: https://doi.org/10.1007/BF01250709

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