Summary
The authors have studied the influence of 2 weeks' treatment of 15 non-diabetic, obese subjects with 2 g of Metformin daily, on intravenous glucose tolerance and plasma insulin levels. Blood glucose fasting and during the IVGTT were not influenced by treatment, but the insulin levels and the insulin/glucose ratios were significantly decreased. This points to a decreased insulin resistance.
Résumé
Les auteurs ont étudié chez 15 obèses non diabétiques, l'influence d'un traitement à la Metformine (2 g/ jour pendant quinze jours) sur la glycémie et le taux d'insulinémie à jeun et après une surcharge glucosée intraveineuse. Le traitement n'influence ni la glycémie à jeun, ni la glycémie après surcharge intraveineuse ni la constante d'assimilation du glucose. L'insulinémie à jeun et après surcharge glucosée est cependant nettement diminuée, de même que le rapport insulinémié/glycémie. Ceci semble indiquer une réduction de la résistance à l'insuline observée chez les obèses non diabétiques.
Zusammenfassung
Die Autoren untersuchten an 15 übergewichtigen, nicht diabetischen Patienten die Beeinflussung des Kohlenhydratstoffwechsels und der Insulin-Sekretion durch eine Behandlung mit Metformin (2g/Tag). Die Blutzuckerwerte, nüchtern und während des intravenösen G.T.T., wurden nicht beeinflußt. Auch die K-Werte zeigten trotz eines leichten Abfalls unter der Behandlung keine statistisch signifikante Abweichung von den Ausgangswerten. Die Insulinspiegel, nüchtern und nach Glucose, waren jedoch unter der Behandlung signifikant gesenkt und der Insulin/Glucose-Quotient erniedrigt. Dies läßt auf eine partielle Aufhebung der Insulinresistenz bei übergewichtigen Patienten schließen.
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Vermeulen, A., Rottiers, R. Influence of dimethylbiguanide (metformin®) on carbohydrate metabolism in obese, non-diabetic women. Diabetologia 8, 8–11 (1972). https://doi.org/10.1007/BF01219980
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DOI: https://doi.org/10.1007/BF01219980