Summary
This report deals with delayed pathological changes observed in the brains of monkeys receiving X- andγ-radiation to the head in a dose of 2000 R given at 50 R/min.
The pathological changes observed in the hypothalamus and the rest of the brain strongly suggested a “vascular factor” as of overriding pathogenic importance in lesion inception.
Zusammenfassung
Bei sieben jugendlichen Macacus-Affen wurden späte neuropathologische Veränderungen des Gehirns nachγ- undX-Bestrahlung des Kopfes beschrieben. Die Dosierung betrug 2000 R bei 50 R pro Minute.
Die Veränderungen im Hypothalamus wurden im einzelnen dargestellt. Starke Gefäßerweiterungen sprechen für einen vascularen Faktor der Strahlenschädigung.
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References
Arnold, A.: Effect of X-irradiation on the hypothalamus: A possible explanation for the therapeutic benefits following X-irradiation of the hypophyseal region for pituitary dysfunction. J. Clin. Endocr.14, 859–868 (1954).
—, andP. Bailey: Alterations in the glial cells following irradiation of the brain in primates. Arch. Path.57, 383–391 (1954).
— — andR. A. Harvey: Intolerance of the primate brainstem and hypothalamus to conventional high energy radiations. Neurology (Minneap.)4, 575–585 (1954).
— — —, andJ. S. Laughlin: Changes in the central nervous system following irradiation with 23-mev X-rays from the betatron. Radiology62, 37–44 (1954).
— —, andJ. S. Laughlin: Effects of betatron radiation on the brain of primates. Neurology (Minneap.)4, 165–178 (1954).
Finley, K. H.: Angio-architecture of the hypothalamus and its peculiarities. Ass. Res. nerv. Dis. Proc.20, 286–309 (1940).
Haymaker, W., M. Z. M. Ibrahim, J. Miquel, N. Call, A. J. Riopelle: Delayed radiation effects in the brains of monkeys exposed to X- andγ-rays. J. Neuropath, exp. Neurol. (in press) (1967).
Lyman, R. S., P. S. Kupalov, andW. Scholz: Effect of roentgen rays on the central nervous system. Results of large doses on the brains of adult dogs. Arch. Neurol. Psychiat. (Chic.)29, 56–87 (1933).
Riopelle, A. J., B. L. Reed, H. L. Williams, andW. Haymaker: Effects of X- and gamma-irradiation of the heads ofMacaca irus monkeys. Radiat. Res. (in press) (1967).
Scholz, W.: Experimentelle Untersuchungen über die Einwirkung von Röntgenstrahlen auf das reife Gehirn. Z. ges. Neurol. Psychiat.150, 765–785 (1934).
—: Über die Empfindlichkeit des Gehirns für Röntgen- und Radiumstrahlen. Klin. Wschr.14, 189–193 (1949).
—: Discussion. In: Reports and Discussions, 3rd Intern. Congr. Neuropathol. p. 272 to 277. Acta Med. Belg., Brussels 1957.
— u.A. Breit: Experimentelle Röntgenspätschäden am Rückenmark des erwachsenen Kaninchens. Ein weiterer Beitrag zur Wirkungsweise ionisierender Strahlen auf das zentralnervöse Gewebe. Psychiat. Neurol. Jap.61, 417–442 (1959).
H. Hager, W. Hirschberger, andA. Breit: “Research on toxicity changes in the central nervous system.” The response of the central nervous system to X-irradiation. Histological and electronmicroscopical investigation. TR, Contract No. AE 61(052)-341 (1961).
—, andW. Hirschberger: Morphological effect of repeated low dosage and single high dosage application of X-irradiation to the central nervous system. In: Response of the nervous system to ionizing radiation, pp. 211–232.T. J. Haley, andR. S. Snider (Eds.) New York: Academic Press, Inc. 1962.
Zeman, W.: Disturbances of nucleic acid metabolism preceding delayed radionecrosis of nervous tissue. Proc. nat. Acad. Sci. (Wash.)5, 626–630 (1963).
—: Strahlenschäden des Nervensystems. Arch. Psychiat. Z. Neurol.206, 185–198 (1964).
—: Oxygen effect and the selective of radiolesions in the mammalian neuroaxis. Proc. 7th Internat. Sympos. Neuroradiolog., New York, Sept., 1964. Acta radiol. (Stockh.) (suppl.)5, 204–216 (1966a).
—: Zur Pathogenese der Strahlenspätschädigung des Rückenmarks. Dtsch. Röntgenkongr., 1965, Tiel B, Strahlenbehandl. u. Strahlenbiol., Sdbde. Strahlentherapie, Bd. 62, p. 68–76. München: Urban & Schwarzenberg (1966b).
—: Pathogenesis of radiolesions in the mature central nervous system. Proc. 5th Internat. Congr. Neuropath., p. 302–308. Amsterdam: Exc. Med. Found. (1966c).
—, andS. Biondo: Cytochemistry of delayed radionecrosis of the murine spinal cord. In: Response of the nervous system to ionizing radiation, p. 105–126.T. J. Haley andR. S. Snider (Eds.). Boston: Little, Brown & Co. 1964.
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National Research Council Postgraduate Resident Research Associate supported by the National Aeronautics and Space Administration.
The brain sections were obtained from the Armed Forces Institute of Pathology, Washington, D. C., where preliminary studies were carried out by Dr.P. Lampert and Dr.R. P. Davis. AFIP accession numbers are indicated in the table.
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Ibrahim, M.Z.M., Haymaker, W., Miquel, J. et al. Effects of radiation on the hypothalamus in monkeys. Arch. F. Psychiatr. U. Z. Neur. 210, 1–15 (1967). https://doi.org/10.1007/BF01217331
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DOI: https://doi.org/10.1007/BF01217331