Summary
Productivity of the fermentation of lactose to ethanol byKluyveromyces fragilis has been significantly improved by coupling a cross-flow membrane module to the primary fermentor in a semi-closed loop configuration. At a cell concentration of 90g/L in the bioreactor and inlet lactose concentration of 150g/L, productivity was 240gETOH/L/hr at dilution rate of 6 hr-1. This was 80 times better than batch fermentation.
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Cheryan, M., Mehaia, M.A. A high-performance membrane bioreactor for continuous fermentation of lactose to ethanol. Biotechnol Lett 5, 519–524 (1983). https://doi.org/10.1007/BF01184942
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DOI: https://doi.org/10.1007/BF01184942