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Export of proteins across membranes: The helix reversion hypothesis

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Bioscience Reports

Abstract

A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.

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Authors and Affiliations

  1. Division of Chemical Engineering, National Chemical Laboratory, 411 008, Pune, India

    U. P. Shinde

  2. Division of Physical Chemistry, Indian Institute of Science, Bangalore

    T. N. Guru Row

  3. Division of Biochemical Sciences, Division of Chemical Engineering, National Chemical Laboratory, 411 008, Pune, India

    Y. R. Mawal

Authors
  1. U. P. Shinde
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  2. T. N. Guru Row
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  3. Y. R. Mawal
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Shinde, U.P., Guru Row, T.N. & Mawal, Y.R. Export of proteins across membranes: The helix reversion hypothesis. Biosci Rep 9, 737–745 (1989). https://doi.org/10.1007/BF01114812

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  • DOI: https://doi.org/10.1007/BF01114812

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