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Purification of human intestinal goblet cell antigen (GOA1), its immunohistological demonstration in the intestine and in mucus producing gastrointestinal adenocarcinomas

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Summary

Goblet cell antigen (GOA1) was purified from gastric signet ring cell carcinoma. It was immunogenic and was used to produce antisera which stained goblet cells of the small and large intestine and of intestinalized gastric mucosa by indirect immunological methods. Various types of gastric and colonic cancer contained GOA1. These findings demonstrate a histiogenic relationship between intestinal goblet cells, various gastrointestinal cancers and associated premalignant conditions.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Institute of Pathology, University of Heidelberg, Heidelberg

    W. Rapp, M. Windisch, P. Peschke & K. Wurster

  2. Institute of Nuclear Medicine, German Cancer Research Center, Heidelberg

    M. Windisch, P. Peschke & K. Wurster

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  1. W. Rapp
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  2. M. Windisch
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  3. P. Peschke
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  4. K. Wurster
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Dedicated to Prof. Dr. W. Doerr on the occasion of his 65th anniversary

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Rapp, W., Windisch, M., Peschke, P. et al. Purification of human intestinal goblet cell antigen (GOA1), its immunohistological demonstration in the intestine and in mucus producing gastrointestinal adenocarcinomas. Virchows Arch. A Path. Anat. and Histol. 382, 163–177 (1979). https://doi.org/10.1007/BF01102872

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  • DOI: https://doi.org/10.1007/BF01102872

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