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Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs

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Abstract

A general treatment for determination of mean residence time (MRTV)and steady-state volume of distribution (V ss )after multiple drug inputs via any mode of administration is presented. For multiple inputs, either simultaneous or consecutive, the mean input time (MIT)can be readily calculated using the general equations presented here. Sample calculations for (MIT, MRT),and V ss following different combinations of multiple drug inputs are presented. Errors inherent in noncompartmental area determinations are discussed.

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Author notes

  1. Nobutoshi Watari

    Present address: School of Pharmaceutical Sciences, Showa University, Hatanodai, Shinagawa-ku, 142, Tokyo, Japan

Authors and Affiliations

  1. Department of Pharmac, School of Pharmacy, University of California, 94143, San Francisco, California

    Nobutoshi Watari & Leslie Z. Benet

Authors
  1. Nobutoshi Watari
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  2. Leslie Z. Benet
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Additional information

This work was supported in part by NIH grants GM26691 and HL32243.

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Watari, N., Benet, L.Z. Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs. Journal of Pharmacokinetics and Biopharmaceutics 17, 593–599 (1989). https://doi.org/10.1007/BF01071351

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  • DOI: https://doi.org/10.1007/BF01071351

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