Journal of Pharmacokinetics and Biopharmaceutics

, Volume 1, Issue 2, pp 137-163

First online:

COMPT, a time-sharing program for nonlinear regression analysis of compartmental models of drug distribution

  • Morris PfefferAffiliated withBiochemistry Department, Endo Laboratories Inc.

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COMPT, a computer program for optimizing the solution of integral compartmental models of drug distribution by nonlinear regression analysis, is written in extended BASIC for use in time-sharing computer systems. It is based on Hartley's modification of the Gauss-Newton gradient method. The characteristics and features of the program are indicated, and the program source listing is presented. This version of COMPT is designed to solve the two-compartment open model of intravenous drug administration. Examples of the results of the operational program are presented. The program is modifiable to permit analytical solutions for other types of systems described by nonlinear equations.

Key words

pharmacokinetics nonlinear regression drug distribution compartmental models computer program BASIC time sharing spectinomycin naloxone