Journal of Pharmacokinetics and Biopharmaceutics

, Volume 1, Issue 2, pp 137–163

COMPT, a time-sharing program for nonlinear regression analysis of compartmental models of drug distribution

  • Morris Pfeffer

DOI: 10.1007/BF01059627

Cite this article as:
Pfeffer, M. Journal of Pharmacokinetics and Biopharmaceutics (1973) 1: 137. doi:10.1007/BF01059627


COMPT, a computer program for optimizing the solution of integral compartmental models of drug distribution by nonlinear regression analysis, is written in extended BASIC for use in time-sharing computer systems. It is based on Hartley's modification of the Gauss-Newton gradient method. The characteristics and features of the program are indicated, and the program source listing is presented. This version of COMPT is designed to solve the two-compartment open model of intravenous drug administration. Examples of the results of the operational program are presented. The program is modifiable to permit analytical solutions for other types of systems described by nonlinear equations.

Key words

pharmacokineticsnonlinear regressiondrug distributioncompartmental modelscomputer programBASICtime sharingspectinomycinnaloxone

Copyright information

© Plenum Publishing Corporation 1973

Authors and Affiliations

  • Morris Pfeffer
    • 1
  1. 1.Biochemistry DepartmentEndo Laboratories Inc.Garden City