Abstract
Human exposure to pentachlorophenol (PCP) was evaluated in the normal population (controls), residents of PCP-treated log homes, and persons exposed primarily in the workplace. Blood and urine samples were analyzed by gas chromatography after extraction and acetylation. For 34 controls, serum PCP values ranged from 15–75 ppb with a mean of 40 ppb. For 123 residents of log homes, serum levels ranged from 69–1,340 ppb with a mean of 420 ppb. In such homes, serum levels for children were significantly higher than those for parents, averaging 1.8 times greater. Serum and urine values for workers varied widely, depending on the workplace, with serum levels ranging from 26 to 84,900 ppb of PCP. Urinary concentrations when corrected for creatinine values correlated well (r=0.92) with serum concentrations. Coating PCP-treated logs of home interiors with a sealant reduced serum PCP levels in the residents.
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References
Alvares AP (1982) Biotransformation of drugs. In: Arias I, Popper H, Schachter D, Shafritz DA (eds) The Liver: Biology and pathobiology, Raven Press, New York, pp 265–280
Bergner H, Constantinidis P, Martin J (1965) Industrial pentachlorophenol poisoning in Winnipeg. Can Med Assoc J 92:448–451
Bevenue A, Beckman H (1967a) Pentachlorophenol: A discussion of its properties and its occurrence as a residue in human and animal tissues. Residue Reviews 19:83–128
Bevenue A, Wilson J, Casarett LJ, Klemmer HW (1967b) A survey of pentachlorophenol content in human urine. Bull Environ Contam Toxicol 2:319–332
Bevenue A, Emerson ML, Casarett LJ, Yauger WL Jr (1968) A sensitive gas Chromatographic method for the determination of pentachlorophenol in human blood. J Chromatogr 38:467–472
Blair DM (1961) Dangers in using and handling sodium pentachlorophenate as a mollusicide. Bull WHO 25:597–601
Bomhard A, Schaller KH, Triebig G (1984) Quantitative determination of pentachlorophenol in human plasma and urine by capillary gas chromatography with ECD and MS detection. Fresenius' Z Anal Chem 319:516–519
Butte W (1985) Pentachlorophenol concentrations in serum and urine of persons that have used wood preserving agents. J Clin Chem Clin Biochem 23(9):599
Cedar F (1984) Historical and current developments of antisapstain chemical use. In: Jeffries E (ed) Proc Symp: Preservatives in the wood industry, Univ of British Columbia, Vancouver, Canada
Centers for Disease Control (1980) Pentachlorophenol in log homes-Kentucky. Morbidity and Mortality Weekly Report 29:431–437
Gomez-Catalan J, To-Figueras J, Planas J, Rodamilans M, Corbella J (1987) Pentachlorophenol and hexachlorobenzene in serum and urine of the population of Barcelona. Human Toxicol 6:397–400
Gray RE, Gilliland RD, Smith EE, Lockard VG, Hume AS (1985) Pentachlorophenol intoxication: Report of a fatal case, with comments on the clinical course and pathologic anatomy. Arch Environ Health 40(3):161–164
Kleinman GD, Horstman SW, Kalman DA, McKenzie J, Stansel D (1986) Industrial hygiene, chemical and biological assessments of exposures to a chlorinated phenolic sapstain control agent. Am Ind Hyg Assoc J 47(12):731–741
Klemmer HW, Wong L, Sato MM, Reichert EL, Korsak RJ, Rashad MN (1980) Clinical findings in workers exposed to pentachlorophenol. Arch Environ Contam Toxicol 9:715–725
Kowal NE, Zirkes M (1983) Urinary cadmium and beta A2-microglobulin: Normal values and concentration adjustment. J Toxicol Environ Health 11:607–624
Kutz FW, Murphy RS, Strassman SC (1978) Survey of pesticide residues and their metabolites in urine from the general population. In: Rao KR (ed) Pentachlorophenol, Plenum Press, New York, pp 366–368
Landrigan PJ, Gehlbach SH, Rosenblum BF, Shoults JM, Candelaria RM, Barthel WF, Liddle JA, Smrek AL, Staehling NW, Sanders JF (1975) Epidemic lead absorption near an ore smelter. N Engl J Med 292(3):123–129
Landrigan PJ, Wilcox KR Jr, Silva J Jr, Humphrey HEB, Kauffman C, Heath CW Jr (1979) Cohort study of Michigan residents exposed to polybrominated biphenyls: Epidemiologic and immunologic findings. Ann New York Acad Sci 320:284–294
National Association of Home Manufacturers (1980) Guide to manufactured homes. Falls Church, Virginia
Needham LL, Cline RE, Head SL, Liddle JA (1981) Determining pentachlorophenol in body fluids by gas chromatography after acetylation. J Anal Toxicol 5(6):283–286
Onishi S, Kawade N, Itoh S, Isobe K, Sugiyama S (1979) Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver. Biochem J 184:705–707
Ratcliffe JM (1981) Lead in man and the environment. John Wiley and Sons, New York, p 27
Uhl S, Schmid P, Schlatter C (1986) Pharmacokinetics of pentachlorophenol in man. Arch Toxicol 58:182–186
Vaughan VC (1983) Nelson textbook of pediatrics, Saunders Co, Philadelphia, pp 25–26
Wagner SL (1983) Clinical toxicology of agricultural chemicals, Noyes Data Corp, Park Ridge, New Jersey, pp 122–137
Williams PL (1982) Pentachlorophenol, an assessment of the occupational hazard. Am Ind Hyg Assoc J 43(11):799–810
Wood S, Rom WN, White GL Jr, Logan DC (1983) Pentachlorophenol poisoning. J Occup Med 25(7):527–530
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Cline, R.E., Hill, R.H., Phillips, D.L. et al. Pentachlorophenol measurements in body fluids of people in log homes and workplaces. Arch. Environ. Contam. Toxicol. 18, 475–481 (1989). https://doi.org/10.1007/BF01055012
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DOI: https://doi.org/10.1007/BF01055012