Skip to main content
Log in

A dilute bootstrap percolation: Lattice model for unresponsiveness in T-cell immunology

  • Articles
  • Published:
Journal of Statistical Physics Aims and scope Submit manuscript

Abstract

The biased majority rule of cellular automata takes a spin up if and only if at least two of its four nearest neighbors on the square lattice are up. We generalize this type of bootstrap percolation by introducing quenched site dilution as well as a random birth and decay process. Our Monte Carlo simulations then give first-order transitions qualitatively similar to our results from meanfield reaction equations describing the induction of T-cell unresponsiveness in the immune system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. A. S. Perelson, ed.,Theoretical Immunology, Vols. I and II (Addison-Wesley, New York, 1988).

    Google Scholar 

  2. M. Blackman, J. Kappler, and P. Marrack,Science 248:1335 (1990).

    Google Scholar 

  3. R. H. Schwartz,Science 248:1349 (1990).

    Google Scholar 

  4. F. Andris, M. Van Mechelen, N. Legrand, P. M. Dubois, M. Kaufman, J. Urbain, and O. Leo,Int. Immun. 3:609 (1991).

    Google Scholar 

  5. M. Kaufman, F. Andris, and O. Leo, Theoretical insight into antigen-induced T-cell unresponsiveness, inTheoretical and Experimental Insights into Immunology, A. S. Perelson and G. Weisbuch, eds. (Springer-Verlag, New York, 1992); M. Kaufman, F. Andris, and O. Leo, A model for antigen-induced T-cell unresponsiveness based on autophosphorylative protein kinase activity, submitted.

    Google Scholar 

  6. P. M. Dubois, F. Andris, R. A. Shapiro, L. K. Gilliland, M. Kaufman, J. Urbain, J. A. Ledbetter, and O. Leo, T cell long term hyporesponsiveness follows antigen receptor engagment and results from defective signal transduction,Eur. J. Immunol., in press.

  7. B. M. Sefton and M.-A. Campbell,Annu. Rev. Cell Biol. 7:257 (1991); A. Veillette and M. Fournel,Oncogene 5:1455 (1990).

    Google Scholar 

  8. J. Adler,Physica A 171:453 (1991).

    Google Scholar 

  9. R. H. Schonmann,Physica A 167:619 (1990); D. Stauffer,Physica Scripta T 35:66 (1991).

    Google Scholar 

  10. C. DeLisi and A. S. Perelson,J. Theor, Biol. 62:159 (1976).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaufman, M., Stauffer, D. A dilute bootstrap percolation: Lattice model for unresponsiveness in T-cell immunology. J Stat Phys 73, 843–851 (1993). https://doi.org/10.1007/BF01052812

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01052812

Key words

Navigation