Abstract
The synthesis of proteoheparan sulfate in hepatocytes is positively regulated under acute-phase conditions produced either by turpentine or deep back incision. In both cases the incorporation of [35S]sulfate and [14C]glucosamine is doubled during a 4-h incubation period if compared with control rat hepatocytes. Neither the fractional secretion rate of heparan sulfate into the medium (< 0.1 of cell-associated glycosaminoglycans) nor the composition of newly formed proteoglycans in hepatocytes are affected during acute phase reaction.
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Djovkar, A., Gressner, A.M. Inflammation-induced synthesis of proteoheparan sulfate: A novel acute-phase reactant in rat hepatocytes. Inflammation 11, 39–46 (1987). https://doi.org/10.1007/BF00917770
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DOI: https://doi.org/10.1007/BF00917770