Abstract
Although decreased posterior cingulate metabolism in Alzheimer's disease (AD) has been previously reported, there have been no reports on posterior cingulate perfusion. In this study we evaluated posterior cingulate perfusion as a relative value using statistical parametric maps (SPMs) and as an absolute value using conventional region of interest (ROI) settings. Twenty-eight subjects, including 14 patients with mild AD (mean age: 66.4±12.1 years) and 14 normal controls (65.9±7.3 years) were studied. Regional Cerebral blood flow (CBF) was measured with H2 15O and positron emission tomography (PET). In the SPM analysis, the left posterior cingulate and left parietotemporal CBFs were significantly decreased in the patients with mild AD (P<0.001). At a louver statistical threshold (P<0.05), the right posterior cingulate and right parietotemporal CBFs were also significantly decreased in the AD patients. In the ROI studies, the left parietal and posterior cingulate CBFs in the patients with mild AD were significantly lower than those of the normal controls by analysis of variance and post-hoc Scheffé's test (P<0.001). We conclude that posterior cingulate perfusion is decreased in mild AD, reflecting the pathological changes and metabolic reduction in the posterior cingulate gyrus that have previously been reported to occur in mild AD.
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References
Herholz K, Perani D, Salmon E, et al. Comparability of FDG PET studios in probable Alzheimer's disease.J Nucl Med 1993; 34: 1460–1466.
Fukuyama H, Ogawa M, Yamauchi H, et al. Altered cerebral energy metabolism in Alzheimer's disease: a PET study.J Nucl Med 1994; 35: 1–6.
Gemmell HG, Sharp PF, Besson JAO, Ebmeier KP, Smith FW. A comparison of Tc-99m-HMPAO and 1-123 IMP cerebral SPECT images in Alzheimer's disease and multi-infaret dementia.Eur J Nucl Med 1988; 14: 463–466.
Ishii K, Kitagaki H, Kono M, Mori E. Decreased medial temporal oxygen metabolism in Alzheimer's disease shown by positron omission tomography.J Nucl Med 1996; 37: 1159–1165.
Minoshima S, Foster NL, Kuhl DE. Posterior cingulate cortex in Alzheimer's disease.Lancet 1994; 344: 895.
McKhann G, Drachman D, Folstein M, Katzman R, Prico D, Stadlan EM. Clinical diagnosis in Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.Neurology 1984, 34: 939–944.
Morris JC. The Clinical Dementia Rating (CDR): current version and screening rules.Neurology 1993; 43: 2412–2414.
Hatazawa J, Fujita H, Kanno I, et al. Regional cerebral blood flow, blood volume, oxygen extraction fraction, and oxygen utilization rate in normal volunteers measured by the autoradiographic technique and the single breath inhalation method.Ann Nucl Med 1995; 9: 15–21.
Friston KJ, Holmes AP, Worsely KJ, Poline JB, Frith CD, Frackowiak RSJ. Statistical parametric maps in functional imaging: a general linear approach.Human Brain Map 1995; 2: 189–210.
Burdotte JH, Minoshima S, Borght TV, Tran DD, Kuhl DE. Alzheimer disease: improved visual interpretation of PET images by using three-dimensional stereotaxic surface projections.Radiology 1996; 198: 8327–843.
Reiman EM, Caselli RJ, Yun LS, et al. Preclinical evidence of Alzheimer's disease in persons homozygous for the ɛ4 allele for apolipoprotein E. N Engl J Med 1996; 334: 752–758.
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Ishii, K., Sasaki, M., Yamaji, S. et al. Demonstration of decreased posterior cingulate perfusion in mild Alzheimer's disease by means of H2 15O positron emission tomography. Eur J Nucl Med 24, 670–673 (1997). https://doi.org/10.1007/BF00841407
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DOI: https://doi.org/10.1007/BF00841407