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Dystonic reactions following neuroleptics: Time Course and proposed mechanisms

  • Human Pharmacology
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Abstract

The occurrence of acute dystonic reactions was studied relative to drug pharmacokinetic parameters following a single dose of the phenothiazine, butaperazine. Dystonias occurred more than one half-life from peak butaperazine levels, 23 to 56 h after drug administration. The authors postulate that the appearance of dystonias on falling plasma concentrations may be due to disruption of dopaminergiccholinergic balance caused by differential antidopaminergic and anticholinergic potencies of the drug.

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Authors and Affiliations

  1. Illinois State Psychiatric Institute, University of Chicago, Chicago, Illinois

    David L. Garver, John M. Davis, Haroutune Dekirmenjian, Stephen Ericksen, Lawrence Gosenfeld & Joseph Haraszti

  2. Department of Psychiatry, University of Chicago, Chicago, Illinois

    David L. Garver, John M. Davis, Haroutune Dekirmenjian, Stephen Ericksen, Lawrence Gosenfeld & Joseph Haraszti

Authors
  1. David L. Garver
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  2. John M. Davis
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  3. Haroutune Dekirmenjian
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  4. Stephen Ericksen
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  5. Lawrence Gosenfeld
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  6. Joseph Haraszti
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Garver, D.L., Davis, J.M., Dekirmenjian, H. et al. Dystonic reactions following neuroleptics: Time Course and proposed mechanisms. Psychopharmacology 47, 199–201 (1976). https://doi.org/10.1007/BF00735822

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  • DOI: https://doi.org/10.1007/BF00735822

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