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Maternal levels of pregnancy-specific β1 (SP-1) are elevated in pregnancies affected by Down's syndrome

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Summary

Concentrations of pregnancy-specific β1-glycoprotein (SP-1) were measured in maternal blood and amniotic fluid of patients with a trisomic fetus and compared with that of a cytogenetically normal fetus at weeks 16–19 of pregnancy. The SP-1 concentrations were significantly elevated in the sera of women with a Down's syndrome fetus, whereas amniotic fluid levels were only slightly increased. It is suggested that high levels of maternal SP-1 in the second trimester of pregnancy may be a valuable indicator in the prenatal detection of fetal trisomy 21.

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Authors and Affiliations

  1. Institut für Humangenetik der Universität, Gosslerstrasse 12d, D-3400, Göttingen, Federal Republic of Germany

    Iris Bartels & Andrea Lindemann

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  1. Iris Bartels
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  2. Andrea Lindemann
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Bartels, I., Lindemann, A. Maternal levels of pregnancy-specific β1 (SP-1) are elevated in pregnancies affected by Down's syndrome. Hum Genet 80, 46–48 (1988). https://doi.org/10.1007/BF00451454

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  • DOI: https://doi.org/10.1007/BF00451454

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