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Antagonism of the anticonflict effects of chlordiazepoxide by β-carboline carboxylic acid ethyl ester, Ro 15-1788 and ACTH(4–10)

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Abstract

The antagonism of the anticonflict effect of chlordiazepoxide (CDP) by β-carboline carboxylic acid ethyl ester (BCCE), Ro 15-1788 and ACTH(4–10) has been evaluated in the Geller-Seifter rat conflict test in which CDP increases punished (conflict), but not unpunished responding. BCCE (0.5–10 μg ICV) produced a dose-dependent reduction in the anticonflict activity of CDP. This was also significantly reduced by Ro 15-1788 (25 mg/kg IP) and a high dose of ACTH(4–10) (5 μg ICV). None of these test compounds had a marked direct effect on punished or unpunished responding in the doses used. These experiments provide further physiological support for the suggestion from binding studies that BCCE and Ro 15-1788 act on benzodiazepine receptors. However, the ability of ACTH(4–10) to reduce the anticonflict effect of CDP may be by some other, possibly opioid, mechanism.

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  1. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, Great Britain

    Sandra V. Vellucci & R. A. Webster

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  1. Sandra V. Vellucci
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  2. R. A. Webster
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Vellucci, S.V., Webster, R.A. Antagonism of the anticonflict effects of chlordiazepoxide by β-carboline carboxylic acid ethyl ester, Ro 15-1788 and ACTH(4–10). Psychopharmacology 78, 256–260 (1982). https://doi.org/10.1007/BF00428161

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  • DOI: https://doi.org/10.1007/BF00428161

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