Skip to main content
Log in

Behavioural effects of amphetamine in a small primate: Relative potencies of the d- and l-isomers

  • Original Investigations
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Acute administration of d-amphetamine (up to 8 mg/kg) or l-amphetamine (up to 12 mg/kg) in the marmoset results in a dose-dependent increase in small head movements (checking), an almost total suppression of activities including eating, grooming, playing, and social interaction, but little change in the amount of movement. Severe stereotypy is seen at high doses of both isomers. The d-isomer has approximately twice the potency of the l-isomer in increasing checking behaviour.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Coyle, J. T., Snyder, S. H.: Catecholamine uptake by synaptosomes in homogenates of rat brain: stereospecificity in different areas. J. Pharmacol. Exp. Ther. 170, 221–231 (1969)

    Google Scholar 

  • Harris, J. E., Baldessarini, R. J.: Uptake of (3H)-catecholamines by homogenates of rat corpus striatum and cerebral cortex: effects of amphetamine analogues. Neuropharmacology 12, 669–679 (1973)

    Google Scholar 

  • Holmes, J. C., Rutledge, C. O.: Effects of the d- and l-isomers of amphetamine on uptake, release and catabolism of norepinephrine, dopamine and 5-hydroxytryptamine in several regions of rat brain. Biochem. Pharmacol. 25, 447–451 (1976)

    Google Scholar 

  • Randrup, A., Munkvad, I.: Stereotyped activities produced by amphetamine in several animal species and man. Psychopharmacologia (Berl.) 11, 300–310 (1967)

    Google Scholar 

  • Scheel-Kruger, J.: Behavioural and biochemical comparison of amphetamine derivatives, cocaine, benztropine and tricyclic anti-depressant drugs. Eur. J. Pharmacol. 18, 63–73 (1972)

    Google Scholar 

  • Segal, D. S.: Behavioral characterisation of d- and l-amphetamine: neurochemical implications. Science 190, 475–477 (1975)

    Google Scholar 

  • Taylor, K., Snyder, S.: Amphetamine: differentiation by d- and l-isomers of behavior involving brain norepinephrine or dopamine. Science 168, 1487–1489 (1970)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Scraggs, P.R., Ridley, R.M. Behavioural effects of amphetamine in a small primate: Relative potencies of the d- and l-isomers. Psychopharmacology 59, 243–245 (1978). https://doi.org/10.1007/BF00426628

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00426628

Key words

Navigation