Abstract
Forty-two normal human subjects were studied in the sleep laboratory for one night each. Fourteen were given placebo at bedtime, 14 took l-tryptophane 1 g, and 14 took l-tryptophane 3 g. Both tryptophane groups had significantly lower sleep latency than the placebo group. The usually discarded ‘first laboratory night’ produces a mild situational insomnia in normal persons and thus can be useful in certain sleep studies.
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References
Davis, D., Tyler, J., Hartmann, E.: Effects on human sleep of l-tryptophane 1 and 2 grams. Sleep Res. 4, 72 (1975)
Hartmann, E., Chung, R.: Sleep-inducing effects of l-tryptophane. J. Pharm. Pharmacol. 24, 252–253 (1972)
Hartmann, E., Chung, R., Chien, C.: l-Tryptophane and sleep. Psychopharmacologia (Berl.) 19, 114–127 (1971)
Hartmann, E., Cravens, J.: Effects of long-term administration of l-tryptophane on human sleep. Sleep Res. 4, 76 (1975)
Hartmann, E., Cravens, J., List, S.: Hypnotic effects of l-tryptophane. Arch. gen. Psychiatry 31, 394–397 (1974)
Hartmann, E., Spinweber, C. L., Ware, C.: l-Tryptophane, l-leucine, and placebo. Sleep Res. 5, 57 (1976)
Rechtschaffen, A., Kales, A.: The manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. National Institutes of Health Publ. 204, 1968
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Hartmann, E., Elion, R. The insomnia of ‘sleeping in a strange place’: Effects of l-tryptophane. Psychopharmacology 53, 131–133 (1977). https://doi.org/10.1007/BF00426482
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DOI: https://doi.org/10.1007/BF00426482