Abstract
Using a sensitive assay system recently developed, dopamine-Β-hydroxylase (DΒH) was examined in the serum of 56 psychiatric patients and 33 normal control subjects. Blood values of this enzyme failed to differentiate between the various diagnostic populations explored and were compatible with values obtained for normal control subjects within the same age range. The findings are critically evaluated and their possible relevance discussed with regard to the role of catecholamines in affective disorders.
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This work was supported by USPHS Grants Nos. 17436 and MH 02717.
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Shopsin, B., Freedman, L.S., Goldstein, M. et al. Serum dopamine-Β-hydroxylase (DΒH) activity and affective states. Psychopharmacologia 27, 11–16 (1972). https://doi.org/10.1007/BF00421952
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DOI: https://doi.org/10.1007/BF00421952