Abstract
In some depressive patients, regarded as therapy-resistant, the antidepressive effect of 1-5-hydroxytryptophan (in combination with a peripheral decarboxylase inhibitor) was ehanced by clomipramine at a dosage which, as such, was suboptimal. This probably means that the therapeutic effect of 1-5-hydroxy-tryptophan is based on increase of serotonin at central serotonin receptors.
This is a preview of subscription content, log in via an institution to check access.
References
Carlsson, A., Corrodi, H., Fuxe, K., Hökfelt, T.: Effect of antidepressant drugs in the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-Β-ethyl metatyramine. Europ. J. Pharmacol. 5, 357–366 (1969)
Carroll, B. J., Mowbray, R. M., Davies, B.: Sequential comparison of 1-tryptophan with E.C.T. in severe depression. Lancet 1970 I, 967–969
Coppen, A., Shaw, D. M., Herzberg, B., Maggs, R.: Tryptophan in the treatment of depression. Lancet 1967 II, 1178
Modigh, K.: Effects of chlorimipramine and protriptyline on the hyperactivity induced by 5-hydroxytryptophan after peripheral decarboxylase inhibition in mice. J. Neural. Trans. 34, 101–109 (1973)
Sano, I.: L-5-hydroxytryptophan (1-5-HTP) Therapie bei endogener Depression. Münch. med. Wschr. 114, 1713–1719 (1972)
Van Praag, H. M., Korf, J., Dols, L. C. W., Schut, T.: A pilot study of the predictive value of the probenecid test in application of 5-hydroxytryptophan as antidepressant. Psychopharmacologia (Berl.) 25, 14–21 (1972)
Van Praag, H. M.: Towards a biochemical typology of depressions? Pharmakopsychiat. (Submitted for publication)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
van Praag, H.M., van den Burg, W., Bos, E.R.H. et al. 5-Hydroxytryptophan in combination with clomipramine in “therapy-resistant” depressions. Psychopharmacologia 38, 267–269 (1974). https://doi.org/10.1007/BF00421379
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00421379