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Relationships of psychotomimetic to anti-serotonin potencies of congeners of lysergic acid diethylamide (LSD-25)

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Summary

  1. 1.

    The psychotomimetic potency of 13 congeners of LSD-25 has been approximately determined in man.

  2. 2.

    With the exception of acetylation of the indole nitrogen, all the changes made in the LSD molecule reduced psychotomimetic potency. Bromination at carbon 2 caused the greatest inactivation.

  3. 3.

    High potency as a serotonin antagonist in isolated smooth muscle preparations was not correlated with high potency as a psychotomimetic.

  4. 4.

    The data do not support but do not disprove the “serotonin deficiency” hypothesis of the LSD psychosis.

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References

  • Abramson, H. A., M. E. Jarvik, M. R. Kaufman, C. Kornetsky, A. Levine and M. Wagner: Lysergic acid diethylamide (LSD-25). I. Physiological and perceptual responses. J. Psychol. (Provincetown), 39, 3 (1955).

    Google Scholar 

  • — and M. D. Baron: Lysergic acid diethylamide (LSD-25) antagonists. II. Development of tolerance in man to LSD-25 by prior administration of MLD-41 (1-Metlryl-d-lysergic acid diethylamide). A.M.A. Arch. Neurol. Psychiat. 79, 201–207 (1958).

    Google Scholar 

  • Cerletti, A., and W. Doepfner: Comparative study on the serotonin antagonism of amide derivatives of lysergic acid and of ergot alkaloids. J. Pharmacol. exp. Ther. 122, 124–136 (1958).

    PubMed  Google Scholar 

  • Cerletti, A., and E. Rothlin: Role of 5-Hydroxytryptamine in mental diseases and its antagonism to lysergic acid derivatives. Nature (Lond.) 176, 785–786 (1955).

    Google Scholar 

  • Gaddum, J. H.: Ciba Foundation Symposium on Hypertension. London: Churchill 1953.

    Google Scholar 

  • Geronimus, L. H., H. A. Abramson and L. J. Ingraham: Lysergic acid diethylamide (LSD-25). XXIII. Comparative effects of LSD-25 and related ergot drugs on brain tissue respiration and on human behavior. J. Psychol. (Provincetown) 42, 157–168 (1956).

    PubMed  Google Scholar 

  • Gogerty, J. H., and J. M. Dille: Pharmacology of d-lysergic acid morpholide (LSM). J. Pharmacol. exp. Ther. 120, 340–348 (1957).

    PubMed  Google Scholar 

  • Isbell, H., R. E. Belleville, H. F. Fraser, A. Wikler and C. R. Logan: Studies on lysergic acid diethylamide. I. Effects in former morphine addicts and development of tolerance during chronic intoxication. A.M.A. Arch. Neurol. Psychiat. 76, 468–478 (1956).

    Google Scholar 

  • C. R. Logan and E. J. Miner: Studies on the diethylamide of lysergic acid (LSD-25). III. Attemptsto attenuate the LSD-reaction in man by pretreat ment with neuro-humoral blocking agents. A.M.A. Arch. Neurol. Psychiat (in press)

  • Jarvik, M. E., H. A. Abramson and M. W. Hirsch: Comparative subjective effects of seven drugs including lysergic acid diethylamide (LSD-25). J. abnorm. soc. Psychol. 51, 657–622 (1955).

    Google Scholar 

  • Murphree, H. B., E. W. J. DeMaar, H. L. Williams and L. L. Bryan: Effects of lysergic acid derivatives on man; antagonism between d-lysergic acid diethylamide and its 2-Bromcongener (Abstract). J. Pharmacol. exp. Ther. 122, 55a-56a (1958).

    Google Scholar 

  • Page, I. H.: Serotonin (5-Hydroxytryptamine); the last four years. Physiol. Rev. 38, 277–335 (1958).

    PubMed  Google Scholar 

  • Rinaldi, F., L. H. Rudy and H. E. Himwich: Clinical evaluation of azacyclonol, chlorpromazine and reserpine on a group of chronic psychotic patients. Amer. J. Psychiat. 112, 678–683 (1956).

    PubMed  Google Scholar 

  • Rothlin, E.: Lysergic acid diethylamide and related substances. Ann. N. Y. Acad. Sci. 66, 668–676 (1957).

    PubMed  Google Scholar 

  • Schneckloth, R., I. H. Page, F. Del Greoo and A. C. Corcoran: Effects of serotonin antagonists in normal subjects and patients with carcinoid tumors. Circulation 16, 523–532 (1957).

    PubMed  Google Scholar 

  • Shore, P. A., S. L. Silver and B. B. Brodie: Interaction of serotonin and lysergic acid diethylamide (LSD) in the central nervous system. Experientia (Basel) 11, 272–273 (1955).

    Google Scholar 

  • Snow, P. J. D., J. E. Lennard-Jones, G. Curzon, and R. S. Stacy: Humoral effects of metastasizing carcinoid tumors. Lancet 1955II, 1004–1009.

  • Solms, H.: Lysergsäure-äthylamid (LAE), ein neues stark sedativ wirkendes Psychoticum aus dem Mutterkorn. Schweiz. med. Wschr. 83, 356–360 (1953).

    PubMed  Google Scholar 

  • Solms, H.: Relationship between chemical structure and psychoses with the use of psychotoxic substances. J. clin. Psychopath. 17, 429–433 (1956).

    Google Scholar 

  • Winter, C. A., and L. Flataker: Studies on heptazone (6-Morpholino-4,4-diphenyl-3-heptanone hydrochloride) in comparison with other analgesic agents. J. Pharmacol. exp. Ther. 98, 305–317 (1950).

    Google Scholar 

  • Wooley, D. W., and E. Shaw: A biochemical and pharmacological suggestion about certain mental disorders. Proc. nat. Acad. Sci. (Wash.) 40, 228–231 (1954a). - Some neurophysiological effects of serotonin. Brit. med. J. 1954b, 122–126.

    Google Scholar 

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Authors and Affiliations

  1. National Institute of Mental Health, Addiction Research Center, U. S. Public Health Service, Lexington, Kentucky

    Harris Isbell, E. J. Miner & C. R. Logan

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  1. Harris Isbell
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  2. E. J. Miner
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  3. C. R. Logan
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Isbell, H., Miner, E.J. & Logan, C.R. Relationships of psychotomimetic to anti-serotonin potencies of congeners of lysergic acid diethylamide (LSD-25). Psychopharmacologia 1, 20–28 (1959). https://doi.org/10.1007/BF00408108

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  • DOI: https://doi.org/10.1007/BF00408108

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