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Some anticholinergic-like behavioural effects of trans (—)-Δ8 tetrahydrocannabinol

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Abstract

Mice were intraperitoneally dosed with trans(−)-Δ 8 tetrahydrocannabinol, various anticholinergic agents, hallucinogenics, or other behaviourally active drugs immediately prior to a habituating experience. The anticholinergic agents and trans(−)-Δ 8 tetrahydrocannabinol inhibited the subsequent influence of the habituating experience relative to the other drugs and to solvent treated subjects. The habituation modifying effects of these drugs were antagonized by tacrine, but not by d-amphetamine. The results suggest that the behavioural effects of tetrahydrocannabinols might involve an anticholinergic mechanism.

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Authors and Affiliations

  1. University of Manitoba, Winnipeg, Canada

    Hugh Brown

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  1. Hugh Brown
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Additional information

The research described herein was done while the author was a Summer Research Fellow at the University of Manitoba.

The author is indebted to Dr. A.B. Morrison,Deputy Director-General, Canadian Food and Drug Directorate, Ottawa, for supplying the trans(−)-Δ 8tetrahydrocannabinol.

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Brown, H. Some anticholinergic-like behavioural effects of trans (—)-Δ8 tetrahydrocannabinol. Psychopharmacologia 21, 294–301 (1971). https://doi.org/10.1007/BF00403868

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  • DOI: https://doi.org/10.1007/BF00403868

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