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Assignment of 22 loci in the rat by somatic hybrid and linkage analysis

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Abstract

Twenty structural genes and two unique anonymous DNA fragments have been mapped in the rat (Rattus norvegicus) with a panel of mouse x rat hybrids and linkage analysis. Ten of the 20 autosomes are represented by at least one of these markers. A new syntenic relationship among rat Chromosome (Chr) 16, mouse Chr 14, and human Chr 10q was established. Results of this study further support the extensive conservation of syntheny between the rat and mouse and, to a lesser degree, between rat and human.

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References

  • Archer III, B.T., Özçelik, T., Jahn, R., Francke, U., Südhof, T.C. (1990). Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. J. Biol. Chem. 265: 17267–17273.

    Google Scholar 

  • Bodmer, W.F., Bailey, C.J., Bodmer, J., Bussey, H.J.R., Ellis, A., Gorman, P., Lucibello, F.C., Murday, V.A., Rider, S.H., Scambler, P., Sheer, D., Solomon, E., Spurr, N.K. (1987). Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature 328, 614–616.

    Google Scholar 

  • Bout, A., Hoovers, J., Bakker, E., Mannens, M., Guerts van Kessel, A., Tager, J., Benne, R., Westerveld, A. (1989). Assignment of the gene coding for human peroxisomal 3-oxoacyl-CoA thiolase (PTHIO) to chromosome region 3p22-23. Cytogenet. Cell Genet. 51, 966 (Abstr.).

    Google Scholar 

  • Brownell, E., Lee, A.S., Pekar, S.K., Pravtcheva, D., Ruddle, F.H., Bayney, R.M. (1991). Glial fibrillary acid protein, an astrocytic-specific marker, maps to human chromosome 17. Genomics 10, 1087–1089.

    Google Scholar 

  • Buchberg, A.M., Brownell, E., Nagata, S., Jenkins, N.A., Copeland, N.G. (1989). A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. Genetics 122, 153–161.

    Google Scholar 

  • Budarf, M., Huebner, K., Emmanuel, B., Croce, C.M., Copeland, N.G., Jenkins, N.A., D'Andrea, A.D. (1990). Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19. Genomics 8, 575–578.

    Google Scholar 

  • Davisson, M.T., Lalley, P.A., Peters, J., Doolittle, D.P., Hillyard, A.L., Searle, A.G. (1991). Report of the Comparative committee for human, mouse and other rodents. Human Gene Mapping 11. Cytogenet. Cell Genet. 58, 1152–1189.

    Google Scholar 

  • Ferguson-Smith, A.C., Ruddle, F.H. (1988). The genomics of human homeobox-containing loci. Pathol. Immunopathol. Res. 7, 119–126.

    Google Scholar 

  • Francke, U., Yang-Feng, T.L., Brissenden, J.E., Ullrich, A. (1986). Chromosomal mapping of genes involved in growth control. Cold Spring Harbor Symp. Quant. Biol. 51, 855–866.

    Google Scholar 

  • Glaser, T., Matthews, K.E., Hudson, J.W., Seth, P., Housman, D.E., Crerar, M.M. (1989). Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively. Genomics 5, 510–521.

    Google Scholar 

  • Glaser T., Lane, J., Houseman, D. (1990). A mouse model of the aniridia-Wilms tumor deletion syndrome. Science 250, 823–827.

    Google Scholar 

  • Hilbert, P., Lindpainter, K., Beckmann, J.S., Serikawa, T., Soubrier, F., Dubay, C., Cartwright, P., DeGouyon, B., Julier, C., Takahasi, S., Vincent, M., Ganten, D., Georges, M., Lathrop, G.M. (1991). Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 353, 521–529.

    Google Scholar 

  • Hino, O., Klein-Szanto, A., Freed, J., Testa, J., Brown, D., Vilensky, M., Yeung, R., Tartof, K., Knudson, A. (1993). Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. Proc. Natl. Acad. Sci. USA, 90, 327–331.

    Google Scholar 

  • Jacob, H., Lindpainter, K., Lincoln, S., Kusumi, K., Bunker, R., Mao, Y.-P., Ganten, D., Dzau, V., Lander, E. (1991). Genetic mapping of a gene causing hypertension in the stronke-prone spontaneously hypertensive rat. Cell 67, 213–224.

    Google Scholar 

  • LaForgia, S., Morse, B., Levy, J., Barnea, G., Cannizzaro, L.A., Li, F., Nowell, P.C., Boghosian-Sell, L., Glick, J., Weston, A., Harris, C.C., Drabkin, H., Patterson, D., Croce, C.M., Schlessinger, J., Huebner, K. (1991). Receptor protein-tyrosine phosphatase γ is a candidate tumor supporessor gene at human chromosome region 3p21. Proc. Natl. Acad. Sci. USA 88, 5036–5040.

    Google Scholar 

  • Levan, G., Szpirer, J., Szpirer, C., Klinga, K., Hanson, C., Islam, M.A. (1991). The gene map of the Norway rat (Rattus norvegicus) and comparative mapping with mouse and man. Genomics 10, 699–718.

    Google Scholar 

  • Moore, K.J., D'Amore-Bruno, M., Korfhagen, T.R., Glasser, S.W., Whitsett, J.A., Jenkins, N.A., Copeland, N.G. (1992). Chromosomal localization of three pulmonary surfactant protein genes in the mouse. Genomics 12, 388–393.

    Google Scholar 

  • Naylor, S.L., Solomon, A., Martinez, P., Schwartz, S., Klinger, K., Yang, F.M., Lalley, P.A. (1987). Mapping genes located near the human cystic fibrosis locus to mouse chromosomes. Cytogenet. Cell Genet. 46, 669 (Abstr.).

    Google Scholar 

  • Naylor, S.L., Marshall, A., Hensel, C., Martinez, P.F., Holley, B., Sakaguchi, A.Y. (1989). The DNF15S2 locus at 3p21 is transcribed in normal lung and small cell lung cancer. Genomics 4, 355–361.

    Google Scholar 

  • Redmond, T.M., Si, J.-S., Barrett, D.J., Borst, D.E., Rainier, S., Kotake, S., Gery, I., Nickerson, J.M. (1989). Synthesis of an immunopathogenic fusion protein derived from a bovine interphotoreceptor retinoid-binding protein cDNA clone. Gene 80, 109–118.

    Google Scholar 

  • Seldin, M.F., Kruh, G.D. (1989). Mapping of Abll within a conserved linkage group on distal mouse chromosome 1 syntenic with human chromosome 1 using an interspecific cross. Genomics 4: 221–223.

    Google Scholar 

  • Serikawa, T., Kuramoto, T., Hilbert, P., Mori, M., Yamada, J., Dubay, C.J., Lindpainter, K., Ganten, D., Guénet, J.-L., Lathrop, G.M., Beckman, J.S. (1992). Rat gene mapping using PCR-analyzed microsatellites. Genetics 131, 701–721.

    Google Scholar 

  • Sukhatme, V.P., Cao, X., Chang, L.C., Tsai-Morris, C.-H., Stamenkovich, D., Ferreira, P.C.P., Cohen, D.R., Edwards S.A., Shows, T.B., Curran, T., Le Beau, M.M., Adamson, E.D. (1988). A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 53, 37–43.

    Google Scholar 

  • Suter, U., Moskow, J.J., Welcher, A.A., Snipes, G.J., Kosaras, B., Sidman, R.L., Buchberg, A.M., Shooter, E.M. (1992). A leucineto-proline mutation in the putative first transmembrane domain of the 22-kDa peripheral myelin protein in the trembler-J mouse. Proc. Natl. Acad. Sci. USA 89, 4382–4386.

    Google Scholar 

  • Szpirer, J., Levan, G., Thörn, M., Szpirer, C. (1984). Gene mapping in the rat by mouse-rat cell hybridization: synteny of the albumin and alpha-foetoprotein genes and assignment to chromosome 14. Cytogenet. Cell Genet. 38, 142–149.

    Google Scholar 

  • Yeung, R., Taguichi, T., Patriotis, C., Makris, A., Tsichlis, P., Levan, K., Levan, G., Tartof, K., Hino, O., Knudson, A., Testa, J. (1993). New markers, D16FC1 and Tp12, differentiate between rat chromosomes 16 and 17. Cytogenet. Cell Genet. 62, 149–152.

    Google Scholar 

  • Yuen, P.S.T., Potter, L.R., Garbers, D.L. (1990). A new form of guanylyl cyclase is preferentially expressed in rat kidney. Biochemistry 29, 10872–10878.

    Google Scholar 

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Yeung, R.S., Hino, O., Vilensky, M. et al. Assignment of 22 loci in the rat by somatic hybrid and linkage analysis. Mammalian Genome 4, 585–588 (1993). https://doi.org/10.1007/BF00361389

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  • DOI: https://doi.org/10.1007/BF00361389

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