Abstract
Groups of rats were exposed simultaneously to manganese chloride (3 mg Mn2+/ml water) through drinking water and lead acetate intraperitoneally at dosages of 5.0, 8.0 and 12.0 mg Pb2+/kg daily for a period of 14 days. The magnitude of changes in the behavioral pattern, contents of biogenic amines and accumulation of lead in the brain of rats simultaneously exposed to the two metals was significantly greater than observed in rats after exposure to either of the metals alone. A definite dose-response relationship was, however, noticed only with the changes in the motoractivity, norepinephrine, 5-hydroxytryptamine levels and in the accumulation of lead in rats simultaneously exposed to manganese and lead. The lowering in the contents of norepinephrine after combined treatment was found to be related with the decrease in the motoractivity in the rats. The exact role of depression in the levels of dopamine and 5-hydroxytryptamine in inducing marked impairment in learning ability and increased aggressive behavior in rats after the combined exposure to manganese and lead could not be ascertained. The overall analysis of the data indicated that the simultaneous exposure to manganese and lead, particularly with highest dose of the latter, may produce serious derangements in the behavioral pattern and levels of biogenic amines in the brain of rats.
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References
Cook L, Weidley E (1956) Behavioral effects of some psychopharmacological agents. Ann NY Acad Sci 66:740–752
Delves HT, Clayton BE, Bicknell J (1973) Concentrations of trace metals in the blood of children. Br J Prev Soc Med 27:100–107
Donaldson J, Pierre T st, Minnich JL, Barbeau A (1973) Determination of Na+, Mg2+, Zn2+, and Mn2+ in rat brain regions. Can J Biochem 51: 87–92
Golter M, Michaelson A (1975) Growth, behavior and brain catecholamines in lead exposed neonatal rats. Science 187:359–361
Joselow MM, Tobias E, Koehler R, Coleman S, Bogden J, Gause D (1978) Manganese pollution in the city environment its relationship to traffic density. Am J Public Health 68:100–107
Kuhn WL, Van Maanen EF (1961) Central nervous system effects of thalidomide. J Pharmacol Exp Ther 134:60–68
Nordberg GF (1978) Factors influencing metabolism and toxicity of metals: A consensus report. Environ Health Perspect 25:3–41
Sadavongvivad C (1970) Pharmacological significance of biogenic amines in the lungs; 5-HT. Br J Pharmacol 38:353–365
Singh NP, Thind IS, Vitale LF, Pawlow M (1976) Lead content of tissues of baby rats born of and nourished by lead poisoned rats. J Lab Clin Med 87:273–280
Tedeschi RE, Tedeschi DH, Mucha A, Cook L, Mattis P, Fellows EJ (1959) Effects of various centrally acting drugs on fighting behavior of mice. J Pharmacol Exp Ther 125:28–34
Underwood EJ (1978) Interaction of trace elements. In: Oehme FW (ed) Toxicity of heavy metals in the environment, part 2. Marcel Dekker Inc., New York Basel
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Chandra, S.V., Ali, M.M., Saxena, D.K. et al. Behavioral and neurochemical changes in rats simultaneously exposed to manganese and lead. Arch Toxicol 49, 49–56 (1981). https://doi.org/10.1007/BF00352071
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DOI: https://doi.org/10.1007/BF00352071