Summary
A 40-year-old male developed 66 months after diagnosis of Hodgkin's disease a non-Hodgkin lymphoma of high grade malignancy. Initially he had been treated by irradiation because of Hodgkin's disease PS IIA. After 2 years of remission he had relapsed and had received MOPP and CCNU. After 2 years without any therapy he developed the secondary neoplasm. With increasing frequency of long term survivors late complications, either therapy related or caused by immunologic defects, are observed.
Similar content being viewed by others
Abbreviations
- NHL:
-
non-Hodgkin lymphoma
- CHOP:
-
cyclophosphamid, hydroxydaunorubicin, oncovin, prednisone
- PS:
-
pathologic stage
References
Armitage JO, Dick FR, Goeken JA, Foucar MK, Gingrich RD (1983) Second lymphoid malignant neoplasms occurring in patients treated for Hodgkin's disease. Arch Intern Med 143, 445–450
Arsenau JC, Sponzo RW, Levin DL, Schnipper LE, Bonner H, Young RC, Canellos GP, Johnson RE, DeVita VT (1972) Nonlymphomatous malignant tumors complicating Hodgkin's disease. N Engl J Med 287: 1119–1122
Berg J (1967) The incidence of multiple primary cancers in the development of further cancer in patients with lymphoma, leukemia and myeloma. J Natl Cancer Inst 38: 741–752
Canellos GP, DeVita VT, Arsenau JC, Whang-Peng J, Johnson REC (1975) Second malignancies complicating Hodgkin's disease in remission. Lancet I: 947–949
Dick FR, Maca RD, Hankenson R (1978) Hodgkin's disease terminating in a T-cell immunoblastic leukemia. Cancer 42: 1325–1329
Fisher IR (1982) Implications of persistent T cell abnormalities for the biology of Hodgkin's disease. Cancer Treat Rep 66: 681–687
Fisher IR (1983) Non-Hodgkin's lymphomas after treatment of Hodgkin's disease. Arch Intern Med 142: 427
Grünwald HW, Rosner F (1982) Acute myeloid leukemia following treatment of Hodgkin's disease. Cancer 50: 676–683
Khayat D, Mary M, Brocheriou C, Jacquillat C (1982) Lymphome non hodgkinien après maladie de Hodgkin chez un malade recevant des hydantoines. Nouv Press Med 35: 2637–2638
Kim HD, Bedetti CD, Boggs DR (1980) The development of non-Hodgkin's lymphoma following therapy for Hodgkin's disease. Cancer 46: 2596–2602
Krikorian JG, Burke JS, Rosenberg SA, Kaplan HS (1979) Occurrence of Non-Hodgkin's lymphoma after therapy for Hodgkin's disease. N Engl J Med 300: 452–458
Neufeld H, Weinerman BH, Kemel S (1978) Secondary malignant neoplasms in patients with Hodgkin's disease. JAMA 239: 2470–2471
Valagussa P, Santoro A, Kenda R, Fossati Bellani F, Franchi F, Banfi A, Rilke F, Bonadonna G (1980) Second malignancies in Hodgkin's disease: a acomplication of certain forms of treatment. Br Med J 280: 216–219
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Heinz, R., Hanak, H. Non-hodgkin lymphoma following hodgkin's disease. Blut 49, 353–357 (1984). https://doi.org/10.1007/BF00320210
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00320210