Summary
Nitrosoazetidine was fed to rats in drinking water at three different concentrations. At 2 mmol (10 mmol total dose) all of the rats died with hepatocellular carcinomas by the 62nd week. This was a greater response than to an equivalent dose of nitrosopyrrolidine. At 0.67 mmol, 6 of 21 rats developed liver tumors, and at 0.17 millimolar 2 of 30 animals had liver tumors. The comparable responses to feeding of nitrosoazetidine-2,2,4,4-d4 were 3 of 21 rats with liver tumors at 0.69 millimolar and 3 of 30 rats with liver tumors at 0.17 mmol. These results show only a small deuterium isotope effect in liver carcinogenesis with nitrosoazetidine.
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Research supported jointly by the Carcinogenesis Program of the National Cancer Institute and the Energy Research and Development Administration under contract with Union Carbide Corporation
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Lijinsky, W., Taylor, H.W. Carcinogenicity of nitrosoazetidine and tetradeuteronitrosoazetidine in sprague-dawley rats. Z. Krebsforsch. 89, 215–219 (1977). https://doi.org/10.1007/BF00308519
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DOI: https://doi.org/10.1007/BF00308519