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Mitosis of maternal lymphocytes in the presence of fetal cells: Possible implication in prenatal diagnosis from fetal blood samples

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Summary

The suppression of proliferation of maternal lymphocytes by the lymphocytes of their own male newborns have been tested in a PHA-induced two-way stimulation system. The mixed lymphocyte cultures of 6 out of 12 such mother/son pairs had 23–50% metaphases with 46,XX karyotype. In 2 more cases 10% maternal metaphases have been observed. Hence, it appears that fetal lymphocytes are unable to suppress the proliferation of maternal cells completely.

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Authors and Affiliations

  1. Institute of Human Genetics, University of Saarland, Universitätskliniken Bau 68, D-6650, Homburg (Saar), Federal Republic of Germany

    J. P. Chaudhuri & K. D. Zang

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  1. J. P. Chaudhuri
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  2. K. D. Zang
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Chaudhuri, J.P., Zang, K.D. Mitosis of maternal lymphocytes in the presence of fetal cells: Possible implication in prenatal diagnosis from fetal blood samples. Hum Genet 34, 307–310 (1976). https://doi.org/10.1007/BF00295295

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  • DOI: https://doi.org/10.1007/BF00295295

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