Summary
The linked alpha-amylase loci Amy 1 and Amy 2 were evaluated for their linkage relationship to the PKU locus using data collected from two (one Czech and one Polish) groups of families. The five sibships informative for Amy 1: PKU give a ž score of 1.505 at θ=0.00 and the eight sibships informative for Amy 2: PKU give a ž score of 2.709 at θ=0.00. Due to the tandem position of Amy 1 and Amy 2 loci, these data could be combined, and linkage between Amy and PKU loci established with a ž score 4.214 at θ=0.00. The practical significance of the linkage, especially for identifying PKU allele carriers, is emphasized.
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Kamarýt, J., Mrskoš, A., Podhradská, O. et al. PKU locus: Genetic linkage with human amylase (Amy) loci and assignment to linkage group I. Hum Genet 43, 205–210 (1978). https://doi.org/10.1007/BF00293596
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DOI: https://doi.org/10.1007/BF00293596