Abstract
Linoleic acid was shown to be the only detectable nematicidal agent in the mycelial extracts of several predacious fungi of the genus Arthrobotrys. Although the compound is present in saprophytic cultures, induction of trap formation by nematodes or phenylalnyl-valine caused a significant increase in its production. In submerged cultures, the number of traps formed by Arthrobotrys conoides and Arthrobotrys oligospora was directly correlated to the increase of the concentration of linoleic acid. In A. conoides, the ratio of ergosterol to linoleic acid decreased from 2.6 in saprophytic cultures to 1.1 in trap-forming cultures induced with nematodes. Linoleic acid exhibited nematicidal activities towards the free-living nematode Caenorhabditis elegans with an LD50 value of 5 μg/ml.
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Stadler, M., Anke, H. & Sterner, O. Linoleic acid — The nematicidal principle of several nematophagous fungi and its production in trap-forming submerged cultures. Arch. Microbiol. 160, 401–405 (1993). https://doi.org/10.1007/BF00252228
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DOI: https://doi.org/10.1007/BF00252228