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Electrolyte and acid-base parameters of rat cerebrospinal fluid

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Summary

Values for various electrolytes and acid-base parameters of rat CSF were determined in adult animals anesthetized with pentobarbital or ether. In addition, the distribution of 5,5-dimethyl-2,4-oxazolidinedione (DMO) between CSF and arterial and venous blood was measured in the same animals. It was found a) that CSF electrolyte and acid-base parameters are the same in ether-and pentobarbital-treated animals; b) that DMO distributions between CSF and blood are not determined solely by pH gradients; and c) that in rat CSF electrolyte concentrations (mEq/l) —Na=148.4; K=3.16, Cl=117.9 —and acid-base values —pH=7.38, H2CO3=1.30 mM/l; HCO3=24.5 mM/l —are very similar to those measured in other species.

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Authors and Affiliations

  1. Department of Pharmacology, University of Utah College of Medicine, Salt Lake City, Utah

    Donal J. Reed, C. D. Withrow & Dixon M. Woodbury

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  1. Donal J. Reed
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  2. C. D. Withrow
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  3. Dixon M. Woodbury
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Additional information

This study was supported, in part, by Grant NB 04553 from the U.S. Public Health Service, National Institutes of Health.

Receipient of U.S. Public Health Service Research Career Development Program Award 1-K3-NB 7779.

Receipient of U.S. Public Health Service Research Career Program Award 5-K6-NB-18, 838.

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Reed, D.J., Withrow, C.D. & Woodbury, D.M. Electrolyte and acid-base parameters of rat cerebrospinal fluid. Exp Brain Res 3, 212–219 (1967). https://doi.org/10.1007/BF00235585

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