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Decrease of myocardial infarct size with desferrioxamine: possible role of oxygen free radicals in its ameliorative effect

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Abstract

The ability of an iron chelator, desferrioxamine, to inhibit the infarct size in in vivo rat heart was assessed. Anaesthetised rats were subjected to coronary artery ligation (CAL) for 72 hr and infarct size was measured macroscopically using TTC staining. Systolic blood pressure and ECG were monitored. Desferrioxamine (10 mg/kg and 20 mg/kg i.v.) administered half an hour after CAL markedly reduced the infarct size. However, drug treatment did not alter the systolic blood pressure of animals. In addition, desferrioxamine in vitro and in vivo demonstrated an inhibition of rat PMN-evoked and luminol-enhanced chemiluminiscence. The capacity of desferrioxamine to impair the generation or to scavenge directly oxygen free radicals may be responsible for its beneficial effect on myocardial infarct size in rats.

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Authors and Affiliations

  1. Division of Pharmacology, Department of Pharmaceutical Sciences, Panjab University, 160014, Chandigarh, India

    Kanwaljit Chopra & Manjeet Singh

  2. Department of Experimental Medicine, Post Graduate Institute of Medical Education and Research, 160012, Chandigarh, India

    Nalini Kaul, Khurshid I. Andrabi & N. K. Ganguly

Authors
  1. Kanwaljit Chopra
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  2. Manjeet Singh
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  3. Nalini Kaul
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  4. Khurshid I. Andrabi
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  5. N. K. Ganguly
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Chopra, K., Singh, M., Kaul, N. et al. Decrease of myocardial infarct size with desferrioxamine: possible role of oxygen free radicals in its ameliorative effect. Mol Cell Biochem 113, 71–76 (1992). https://doi.org/10.1007/BF00230887

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  • DOI: https://doi.org/10.1007/BF00230887

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