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Plasma protein induction by isolated hepatocytes

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Summary

Hepatocytes can be maintained in culture for periods of a few hours to many days. This review summarizes the metabolic characteristics of these cultures and describes their use in studying the regulation of plasma protein synthesis. Hormones selectively stimulate the synthesis of certain proteins. Cortisol stimulates the synthesis of fibrinogen and other acute-phase proteins; whereas, insulin stimulates albumin synthesis. In the latter case insulin increases the rate of a nuclear process. Mediators elaborated by leukocytes stimulate acute-phase protein synthesis in hepatocytes. Plasmin-generated fibrin peptides stimulate fibrinogen synthesis via a leukocytic mediator. Lipoprotein synthesis is stimulated by fatty acids and is inhibited by albumin and other macromolecules. These and other processes are susceptible to detailed analysis using sub-cellular fractions (mRNA, nuclei, transcription factors, etc.) isolated from hepatocytes. Studies on fetal or embryonic hepatocytes and hepatomas are yielding information on the regulation of secretory protein synthesis during development and following neoplastic transformation.

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References

  • Alper, L. A., Raum, D., Awdeh, Z., Peterson, B., Taylor, P. and Starzl, T., 1980. Clin. Immunol. Immunopathol. 16: 84–89.

    Google Scholar 

  • Ballard, J. F., in Biochemical Actions of Hormones, 1980. G. Litwack, ed., Academic Press, N.Y. 7: 91–117.

  • Barnhardt, M. I., Cress, D. C., Noonan, S. M. and Walsh, R. T., 1970. Thromb. Diath. Haemorrh. Suppl. 39: 143–159.

    Google Scholar 

  • Barnhardt, M. I. and Noonan, S. M., 1973. Thromb. Diath. Haemorrh. Suppl. 54: 59–82.

    Google Scholar 

  • Bausserman, L. L., Herbert, P. N. and Mc Adam, K. P. N. J., 1980. J. Exp. Med. 152: 641–656.

    Google Scholar 

  • Belanger, L., Hamel, D., Dufour, D., Gudlouzo, A. and Chin, J. F., 1978. Scand. J. Imunol. 8, Suppl. 8: 239–246.

    Google Scholar 

  • Bell-Quint, J. and Forte, T., 1981. Biochim. Biophys. Acta 663: 83–98.

    Google Scholar 

  • Benditt, E. P. and Ericksen, N., 1977. Proc. Natl. Acad. Sci. USA 74: 4025–4028.

    Google Scholar 

  • Berson, M. D. and Kleiner, E., 1980. J. Immunol. 124: 495–499.

    Google Scholar 

  • Bissell, D. M. and Guzelian, P. S., 1980. Ann. N. Y. Acad. Sci. 349: 85–98.

    Google Scholar 

  • Berry, M. R. and Friend, D. S., 1969. J. Cell Biol. 43: 506–520.

    Google Scholar 

  • Bocci, V. and Pacini, A., 1973. Thromb. Diath. Haemorrh. 29: 63–75.

    Google Scholar 

  • Bogenhagen, D. F., Wormington, W. M. and Brown, D. D., 1982. Cell 28: 413–421.

    Google Scholar 

  • Borges, D., Webster, M., Gurmaraes, J. and Prado, J., 1981. Biochem. Pharmacol. 30: 1065–1069.

    Google Scholar 

  • Bouney, R. J., Becker, J. E., Walker, P. R. and Potter, V. R., 1974. In Vitro 8: 399–413.

    Google Scholar 

  • Broeze, R. J., Dougherty, J. P. and Lengyel, P., 1980. Fed. Proc. Am. Soc. Exp. Biol. 39: 2205.

    Google Scholar 

  • Brot, N. and Weisbach, H., 1981. Mol. Cell. Biochem. 36: 47–63.

    Google Scholar 

  • Brown, P. C. and Papaconstantinou, J., 1979. J. Biol. Chem. 254: 9379–9384.

    Google Scholar 

  • Bush, J. A., Mahoney, J. P., Markowitz, H., Gubler, C., Cartwright, G. and Wintrobe, M., 1955. J. Clin. Invest. 34: 1766–1778.

    Google Scholar 

  • Byers, S. O. and Friedman, M., 1960. Am. J. Physiol. 198: 629–631.

    Google Scholar 

  • Cavalieri, R. L., Havell, E. A., Vilcek, J. and Pestka, S., 1977. Proc. Natl. Acad. Sci. USA 74: 4415–4419.

    Google Scholar 

  • Chen, C. C. L. and Feigelson, P., 1980. Ann. N.Y. Acad. Sci. 349: 28–45.

    Google Scholar 

  • Courtoy, P. J., Lombart, C., Feldman, G., Moguilewsky, M. and Rogier, E., 1981. Lab. Invest. 44: 105–115.

    Google Scholar 

  • Crane, L. J., Greenblatt, C. and Miller, D. L., 1975. Fed. Proc. 34: 620.

    Google Scholar 

  • Crane, L. J. and Miller, D. L., 1974. Biochem. Biophys. Res. Commun. 60: 1269–1277.

    Google Scholar 

  • Crane, L. J. and Miller, D. L., 1977. J. Cell. Biol. 72: 11–25.

    Google Scholar 

  • Davis, R. A., Engelhorn, S. C., Pangburn, S. H., Weinstein, D. B. and Sternberg, D., 1979. J. Biol. Chem. 254: 2010–2016.

    Google Scholar 

  • Davis, R. A., Engelhorn, S. C., Weinstein, D. B. and Sternberg, D., 1980. J. Biol. Chem. 255: 2039–2045.

    Google Scholar 

  • de Nechaud, B., Becker, J. E. and Potter, V. R., 1976. Biochem. Biophys. Res. Commun. 68: 8–15.

    Google Scholar 

  • Dickson, A. J. and Pogson, C. L., 1980. Biochem. J. 186: 35–45.

    Google Scholar 

  • Dumont, J. E., Willems, C., Von Sande, J. and Neve, P., 1971. Ann. N.Y. Acad. Sci. 185: 291–316.

    Google Scholar 

  • Ericksson, S., Alm, R. and Astedt, B., 1978. Biochim. Biophys. Acta 542: 496–505.

    Google Scholar 

  • Feldhoff, R. C., Taylor, J. M. and Jefferson, L. S., 1977. J. Biol. Chem. 252: 3611–3616.

    Google Scholar 

  • Fujita, S., Ishizuka, H., Kamimura, N., Kaneda, H. and Ariga, K., 1975. Ann. N.Y. Acad. Sci. 259: 217–220.

    Google Scholar 

  • Fuller, G. M. and Ritchie, D. G., 1982. Proc. Natl. Acad. Sci. (in press).

  • Fuller, G. M., Baglia, F. A., Rupp, R. G., Bohmfalk, J. F., Nickerson, J. M., Miller, R. L. and Milner, P. W., 1979. J. Cell. Biol. 83: 419a.

    Google Scholar 

  • Ginsberg, B. G., 1977. In Biochemical Actions of Hormones, G. Litwack, ed., Academic Press, N.Y. 4: 313–349.

  • Gitlin, D. and Gitlin, J., 1975. Plasma Proteins Vol. II. F. Putnam, ed. Acad. Press 264–318.

  • Glenner, G., 1980a. N. E. J. Med. 302: 1283–1292.

    Google Scholar 

  • Glenner, G., 1980e. N. E. J. Med. 302: 1333–1343.

    Google Scholar 

  • Gordon, A. H., 1970. In: Plasma Protein Metabolism, M. A. Rothschild and T: Waldman, eds. Acad. Press 351–368.

  • Gorin, M. B., Cooper, D. L., Eifermam, F., Nan de Rijn, P. and Tilghman, S. M., 1981. J. Biol. Chem. 256: 1954–1959.

    Google Scholar 

  • Graves, C. B., Munns, T. W., Carlisle, T. L., Grant, G. A. and Strauss, A. W., 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 4772–4776.

    Google Scholar 

  • Green, M. and Miller, L. L., 1960. J. Biol. Chem. 235: 3203–3208.

    Google Scholar 

  • Greengrad, O., Federman, M. and Knox, W. E., 1972. J. Cell Biol. 52: 261–272.

    Google Scholar 

  • Grieninger, G. and Granick, S., 1975. Proc. Natl. Acad. Sci. U.S.A. 72: 5007–5011.

    Google Scholar 

  • Gurr, J. A. and Potter, V. R., 1980. Ann. N.Y. Acad. Sci. 349: 57–66.

    Google Scholar 

  • Hertzberg, K. M., Pindyck, J., Mossesson, M. W. and Grieninger, G., 1981. J. Biol. Chem. 256: 563–566.

    Google Scholar 

  • Hoffman, J. S. and Benditt, E. P., 1981. Fed. Proc. 40: 344.

    Google Scholar 

  • Hooper, D. C., Steer, C. J., Dinarello, C. A. and Peacock, A. C., 1981. Biochim. Biophys. Acta 653: 118–129.

    Google Scholar 

  • Ichihara, A., Nakamura, T., Tanaka, K., Tomita, Y., Aoyama, K., Kato, S. and Shinno, H., 1980. Ann. N.Y. Acad. Sci. 349: 77–84.

    Google Scholar 

  • Ingram, R. S., Scott, R. W. and Tilghman, S. M., 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 4694–4698.

    Google Scholar 

  • Innis, M. A. and Miller, D. L., 1977. J. Biol. Chem. 252: 8469–8475.

    Google Scholar 

  • Innis, M. A. and Miller, D. L., 1979. J. Biol. Chem. 254: 9148–9154.

    Google Scholar 

  • Innis, M. A. and Miller, D. L., 1980. J. Biol. Chem. 255: 8994–8996.

    Google Scholar 

  • Ittyerah, T., Ray, N., Weidner, R., Wachner, D. and Sherman, L. A., 1979. Br. J. Haematol. 43: 661–668.

    Google Scholar 

  • Jansen, H., Kalkman, C., Zonneveld, A. and Hulsmann, W. C., 1979. FEBS Lett. 98: 299–302.

    Google Scholar 

  • Jeejeebhoy, K. N., Ho, J., Greenberg, G. R., Phillips, M. J., Bruce-Robertson, A. and Sodtke, U., 1975. Biochem. J. 146: 141–155.

    Google Scholar 

  • Jeejeebhoy, K. N., Ho, J., Mehra, R., Jeejeebhoy, J. and Bruce-Robertson, A., 1977. Biochem. J. 168: 374–382.

    Google Scholar 

  • Jeejeebhoy, K. N., Phillips, M. J., Ho, J. and Bruce-Robertson, A., 1980. Ann. N.Y. Acad. Sci. 349: 18–27.

    Google Scholar 

  • Jefferson, L. S. and Kerner, A., 1969. Biochem. J. 111: 703–712.

    Google Scholar 

  • John, D. W. and Miller, L. L., 1966. J. Biol. Chem. 241: 4817–4824.

    Google Scholar 

  • John, D. W. and Miller, L. L., 1969. J. Biol. Chem. 244: 6134–6142.

    Google Scholar 

  • Kafotos, F. C., 1972. Curr. Topics Devel. Biol. 7: 125–192.

    Google Scholar 

  • Kaign, M. E. and Prince, A. M., 1971. Proc. Natl. Acad. Sci. U.S.A. 68: 2396–2400.

    Google Scholar 

  • Kato, S., Aoyama, K., Nakamura, T. and Ichihara, A., 1979. J. Biochem. 86: 863–870.

    Google Scholar 

  • Kessler, C. M. and Bell, W. R., 1980. Blood 55: 40–47.

    Google Scholar 

  • Koch, K. S. and Leffert, H. L., 1980. Ann. N. Y. Acad. Sci. 349: 111–127.

    Google Scholar 

  • Knowles, B. B., Howe, C. C. and Aden, D. P., 1980. Science 209: 497–499.

    Google Scholar 

  • Kurtz, D. T., Sippel, A. E., Ansah-Yiadom, R. and Feigelson, P., 1976. J. Biol. Chem. 251: 3594–3598.

    Google Scholar 

  • Kurtz, D. T.: and Feigelson, P., 1977. Proc. Natl. Acad. Sci. U.S.A. 74: 4791–5.

    Google Scholar 

  • Kurtz, D. T., Sippel, A. E. and Feigelson, P., 1976. Biochemistry 15: 1031–1036.

    Google Scholar 

  • Kushner, I. and Feldmann, G., 1978. J. Exp. Med. 148: 466–477.

    Google Scholar 

  • Kushner, I., Broden, M. I. and Karp, D., 1978. J. Clin. Invest. 61: 235–242.

    Google Scholar 

  • Kushner, I., Ribick, W. N. and Blair, J. B., 1976. In: Protides of the Biological Fluids, H. Peeters, ed., Pergamon, N. Y. pp. 471–474.

  • Laurell, C. B. and Jeppson, J. O., 1975. In: The Plasma Proteins, F. W. Putnam, ed., Acad. Press, pp. 229–265.

  • Leffert, H., Koch, K. S., Moran, J. and Williams, M., 1979. Methods Enzymol. 58: 536–544.

    Google Scholar 

  • Leffert, H. L., Moran, T., Boorstein, R., and Koch, K. S., 1977. Nature 267: 58–61.

    Google Scholar 

  • Leffert, H., Moran, T., Sell, S., Shelly, H., Ibsen, K., Mueller, M. and Aries, I., 1978. Proc. Nat. Acad. Sci. U.S.A. 75: 1834–1838.

    Google Scholar 

  • Leibovitz, A., 1963. Am. J. Hyg. 78: 173–180.

    Google Scholar 

  • Le Guilly, Y., Lenoir, P. and Bourel, M., 1973. Biomedicine 19: 361–364.

    Google Scholar 

  • Levin, D. H., Ranu, R. S., Ernst, V. and London, I. M., 1976. Proc. Natl. Acad. Sci. U.S.A. 73: 3112–3116.

    Google Scholar 

  • Levin, M., Franklin, E. C., Frangione, B. and Pras, M., 1972. J. Clin. Invest. 51: 2773–2776.

    Google Scholar 

  • Liao, W. S. L., Hamilton, R. W. and Taylor, J. M., 1980. J. Biol. Chem. 255: 8046–8049.

    Google Scholar 

  • Macintyre, S. S., Schultz, D. and Kushner, I. 1982. Ann. N.Y. Acad. Sci. 389: 76–87.

    Google Scholar 

  • Marsh, J. B., 1974. J. Lipid Res. 15: 85–90.

    Google Scholar 

  • Mc Adam, K. P. W. J., Bausserman, L., Herbert, P. H. and Green, K. M., 1980. In: Amyloid and Amyloidosis, G. Glenner, P. Pinho e Costa and A. Falcao de Freitos, eds. Excerpta Medica, Amsterdam, 302–312.

  • Michalopolous, G. and Pitot, H. C., 1975. Exp. Cell. Res. 94: 70–78.

    Google Scholar 

  • Miller, L. L., 1961. In: Recent. Prog. Horm. Res. 17: 539–568.

    Google Scholar 

  • Miller, L. L. and Bale, W. F., 1954. J. Exp. Med. 99: 125–132.

    Google Scholar 

  • Miller, L. L. and John, D. W., 1970. In: Plasma Protein Metabolism: Regulation of Synthesis, Distribution and Degradation. M. A. Rothschild and T: Waldmann, ed. Academic Press, N. Y. pp. 207–222.

  • Miller, L. L., Schalch, D. S. and Draznin, B., 1980. Endocrinology 108: 1265–1271.

    Google Scholar 

  • Morrow, J. F., Stearman, R. S., Peltzman, C. G. and Potter, D. A., 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 4718–4722.

    Google Scholar 

  • Mortimore, G. E. and Mondon, C. E., 1970. J. Biol. Chem. 245: 2375–2383.

    Google Scholar 

  • Motwani, N. M., Unakar, N. J. and Roy, A. K., 1980. Endocrinology 107: 1606–1613.

    Google Scholar 

  • Munns, T. W., Johnston, M. F. M., Liszewski, M. K. and Olson, R. E., 1976. Proc. Natl. Acad. Sci. U.S.A. 73: 2803–2807.

    Google Scholar 

  • Malawista, S. and Weiss, M., 1974. Proc. Natl. Acad. Sci. USA 71: 927–931.

    Google Scholar 

  • Nasjletti, A. and Masson, G., 1972. Suppl. II Circulation Res. 31: 187–198.

    Google Scholar 

  • Otis, P. T. and Rapapport, S. I., 1973. Proc. Sec. Exptl. Biol. 144: 124–129.

    Google Scholar 

  • Palmiter, R. D., 1975. Cell 1: 89–97.

    Google Scholar 

  • Palmiter, R. D., Moore, P. B., Malvihill, E. R. and Emtage, S., 1976. Cell 8: 557–572.

    Google Scholar 

  • Peavey, D. E., Taylor, J. M. and Jefferson, L. S., 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 5879–5883.

    Google Scholar 

  • Peavey, D. E., Taylor, J. M. and Jefferson, L. S., 1979. Diabetes 28: 390.

    Google Scholar 

  • Pepys, M. B., Dash, A. C., Markham, R. E., Thomas, H. C., Williams, B. D. and Petrie, A., 1978. Clin. Exp. Immunol. 32: 119–124.

    Google Scholar 

  • Peters, T., Jr., 1973. Am. J. Physiol. 224: 1363–1368.

    Google Scholar 

  • Phillips, M. J., Oda, M. and Edwards, V. D., 1974. Lab. Invest. 31: 533–542.

    Google Scholar 

  • Plant, P. W., Liang, T. J., Pindyck, J. and Grieninger, G., 1981. Biochim. Biophys. Acta 655: 407–412.

    Google Scholar 

  • Poli, A., Gordon, P. B., Schwarze, P. E., Grinde, B. and Seglen, P. O., 1981. J. Cell Sci. 48: 1–18.

    Google Scholar 

  • Prunier, J. H., Bearn, A. G. and Cleve, H., 1964. Proc. Soc. Exp. Biol. Med. 115: 1005–1007.

    Google Scholar 

  • Rash, J. M., Rothblatt, G. H. and Sparks, C., 1981. Biochim. Biophys. Acta 666: 294–298.

    Google Scholar 

  • Reid, L. M., Gaitmaitan, Z., Arias, I., Ponce, P. and Rojkind, M., 1980. Ann. N.Y. Acad. Sci. 349: 70–76.

    Google Scholar 

  • Rotermund, H. M., Schreiber, G., Maeno, H., Weinssen, U. and Weigand, K., 1970. Cancer Research 30: 2139–46.

    Google Scholar 

  • Roy, A. K., Schlop, M. J. and Dowbenko, D. J., 1976. FEBS Lett. 64: 396–399.

    Google Scholar 

  • Rubin, K., Oldberg, A., Hook, M. and Obrink, B., 1978. Exp. Cell Res. 117: 165–177.

    Google Scholar 

  • Ruoslahti, E. and Terry, W. D., 1976. Nature 260: 804–805.

    Google Scholar 

  • Rupp, R. G. and Fuller, G. M., 1979. Biochem. Biophys. Res. Commun. 88: 327–334.

    Google Scholar 

  • Sarcione, E. J., 1970. In: Plasma Protein Metabolism ed. M. A. Rothschild and T: Waldmann, Acad. Press, N.Y. 370–382.

  • Sarcione, E. J. and Bogden, A. E., 1966. Science 153: 547–548.

    Google Scholar 

  • Sassa, S. and Kappas, A., 1977. J. Biol. Chem. 252: 2428–2436.

    Google Scholar 

  • Sato, G., 1974. Methods Enzymol. 32B: 557–561.

    Google Scholar 

  • Savage, C. R., Jr. and Bonney, R. J., 1978. Exp. Cell Res. 114: 307–315.

    Google Scholar 

  • Schultz, D., Macintyre, S. and Kushner, I., 1980. Proc. N.Y. Acad. Sci. 349: 387–88.

    Google Scholar 

  • Schwarze, P. E. and Seglen, P. O., 1980. Exp. Cell Res. 130: 185–190.

    Google Scholar 

  • Schwarze, P. E. and Seglen, P. O., 1981. In Vitro 17: 71–76.

    Google Scholar 

  • Schwarze, P. E., Solheim, A. E., Seglen, P. O., 1982. In Vitro 18: 43–54.

    Google Scholar 

  • Seglen, P. O., 1976. Biochim. Biophys. Acta 442: 391–404.

    Google Scholar 

  • Seglen, P. O. and Fossa, J., 1978. Exp. Cell Res. 116: 199–206.

    Google Scholar 

  • Seglen, P. O., Solheim, A. E., Grinde, B., Gordon, P. B., Schwarze, P. E., Gjessing, R. and Poli, A., 1980. Ann. N.Y. Acad. Sci. 349: 1–17.

    Google Scholar 

  • Selinger, M. J., McAdam, K. P. N. J., Kaplan, M. M., Sipe, J. D., Vogel, S. N. and Rosenstreich, D. L., 1980. Nature 285: 498–500.

    Google Scholar 

  • Sell, S. and Morris, H. P., 1974. Cancer Res. 34: 1413–1417.

    Google Scholar 

  • Sell, S., Skelly, H., Leffert, N. C., Muller-Eberhard, U. and Kida, S., 1975. Ann. N.Y. Acad. Sci. 259: 45–58.

    Google Scholar 

  • Sippel, A. E., Feigelson, P. and Roy, A. K., 1975. Biochemistry 14: 825–829.

    Google Scholar 

  • Sirica, A. E., Richards, W., Tsukada, Y., Sattler, C. A. and Pitot, H. C., 1979. Proc. Nat. Acad. Sci. U.S.A. 76: 283–287.

    Google Scholar 

  • Smith, J. E., Borek, C. and Goodman, D. S., 1978. Cell 15: 865–873.

    Google Scholar 

  • Spence, J. T., Hoors, L., Edwards, A., Bosch, A. and Pitot, H. C., 1980. Ann. N.Y. Acad. Sci. 349: 99–109.

    Google Scholar 

  • Stanchfield, J. E. and Yager, J. D., 1979. J. Cell Physiol. 100: 279–290.

    Google Scholar 

  • Struck, D. K., Siuta, P. B., Lane, M. D. and Lennarz, W. J., 1978. J. Biol. Chem. 253: 5332–5337.

    Google Scholar 

  • Sun, J. D. and Holden, D., 1978. J. Biol. Chem. 253:6832–6836.

    Google Scholar 

  • Taketa, K., Watanabe, A. and Kasaka, K., 1975. Ann. N.Y. Acad. Sci. 259: 80–84.

    Google Scholar 

  • Tanaka, K., Kishi, K. and Ichihara, A., 1979. J. Biochem. 86: 863–870.

    Google Scholar 

  • Tanaka, K., Sato, M., Tomita, Y. and Ichihara, A., 1978. J. Biochem. 84: 937–946.

    Google Scholar 

  • Weigand, K., Wernze, H. and Falge, C., 1977. Biochem. Biophys. Res. Commun. 75: 102–110.

    Google Scholar 

  • Westermark, P., 1982. Biochim. Biophys. Acta 701: 19–23.

    Google Scholar 

  • Williams, G. M. and Gunn, J. M., 1974. Experimental Cell Res. 89:139–142.

    Google Scholar 

  • Woodside, K. H. and Mortimore, G. E., 1972. J. Biol. Chem. 247:4774–81.

    Google Scholar 

  • Yeoh, G. C. T., Wassenburg, J. A., Adkins, E. and Oliver, I. T., 1979. Biochim. Biophys. Acta 565: 347–355.

    Google Scholar 

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  1. Research Dept. J. T. Baker Chemical Co., 08865, Phillipsburg, N.J.

    Laura J. Crane

  2. New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, 10314, Staten Island, N. Y., USA

    David L. Miller

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Crane, L.J., Miller, D.L. Plasma protein induction by isolated hepatocytes. Mol Cell Biochem 53, 89–109 (1983). https://doi.org/10.1007/BF00225248

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