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Implementing an intensified antibiotic stewardship programme targeting cephalosporin and fluoroquinolone use in a 200-bed community hospital in Germany

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Abstract

Background

Prescription of third-generation cephalosporins and fluoroquinolones has been linked to an increasing incidence of gram-negative bacteria producing extended-spectrum beta-lactamases, methicillin-resistant Staphylococcus aureus and nosocomial infection with Clostridium difficile. Antibiotic stewardship (ABS) programmes offer evidence-based tools to control antibiotic prescription rates and thereby influence the incidence of nosocomial infection and contain the development of multidrug-resistant bacteria, but there is limited experience with such programmes at community hospitals.

Methods

We implemented an ABS programme at a 200-bed community hospital and aimed at a > 30 % reduction of cephalosporin and fluoroquinolone consumption within 1 year. Pharmacy data were obtained to estimate hospital-wide drug use density expressed in WHO-ATC-defined daily doses (DDD) or hospital-adapted recommended daily doses (RDD) per 1,000 patient days. The effect of the ABS intervention on drug use density was analysed using interrupted time-series analysis for the periods between January 2011 and March 2013 as pre-intervention, and between April 2013 and March 2014 as post-intervention period. The CDI incidence was calculated based on microbiology laboratory data.

Results

Cephalosporin use (measured in RDD/1,000 patient days) decreased by 33 %, and fluoroquinolone use decreased by 31 %, respectively. Interrupted time-series analysis confirmed significant changes in the drug use density trends for both cephalosporins and fluoroquinolones after the intervention as well as for total antibiotic use that decreased by 11 % while no significant effect was noted for CDI incidence rates.

Conclusion

ABS programmes can be effective in community hospitals and may help establish ecologically advantageous antibiotic strategies when needed.

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Conflict of interest

On behalf of all the authors, the corresponding author states that there is no conflict of interest.

Ethical statement

The ethics committee was notified about the trial––formal approval was not required, because the project is based on epidemiological data. Research involving human subjects, human material, specific human or personalised data was not carried out.

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Authors and Affiliations

  1. Ortenauklinikum Achern, Medizinische Klinik, Sektion Infektiologie, Josef-Wurzler-Straße 7, 77855, Achern, Germany

    J. P. Borde & M. Ruhnke

  2. Ortenauklinikum Achern, Medizinische Klinik, 77855, Achern, Germany

    R. Feik

  3. Division of Infectious Diseases, Department of Medicine, University Medical Center, 79106, Freiburg i.Br., Germany

    W. V. Kern

  4. Ortenauklinikum Offenburg-Gengenbach, Pharmacy Service, Ebertplatz 12, 77654, Offenburg, Germany

    S. Litterst

  5. Center for Medical Biometry and Informatics, University Medical Center, 79106, Freiburg i.Br., Germany

    K. Kaier

  6. Division of Pediatric Infectious Diseases, Department of Pediatrics, von Haunersches Kinderspital, 80337, Munich, Germany

    J. Hübner

  7. Universitätsklinikum Carl Gustav Carus, Zentralbereich Infektiologie, Fetscherstraße 74, 01307, Dresden, Germany

    K. deWith

Authors
  1. J. P. Borde
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  2. S. Litterst
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  3. M. Ruhnke
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  4. R. Feik
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  5. J. Hübner
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  6. K. deWith
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  7. K. Kaier
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  8. W. V. Kern
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Corresponding author

Correspondence to J. P. Borde.

Additional information

K. Kaier and W. V. Kern have equally contributed.

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Borde, J.P., Litterst, S., Ruhnke, M. et al. Implementing an intensified antibiotic stewardship programme targeting cephalosporin and fluoroquinolone use in a 200-bed community hospital in Germany. Infection 43, 45–50 (2015). https://doi.org/10.1007/s15010-014-0693-2

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  • DOI: https://doi.org/10.1007/s15010-014-0693-2

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