Case Report

Infection

, Volume 40, Issue 4, pp 441-443

First online:

Fatal dengue hemorrhagic fever imported into Germany

  • J. Schmidt-ChanasitAffiliated withDepartment of Virology, Clinical Virology Laboratory, Bernhard Nocht Institute for Tropical Medicine Email author 
  • , K. Tenner-RaczAffiliated withDepartment of Pathology, Bernhard Nocht Institute for Tropical Medicine
  • , D. PoppertAffiliated withAcademy for Psychosomatic Medicine and Psychotherapy
  • , P. EmmerichAffiliated withDepartment of Virology, Clinical Virology Laboratory, Bernhard Nocht Institute for Tropical Medicine
  • , C. FrankAffiliated withRobert Koch Institute
  • , C. DingesAffiliated withDepartment of Forensic Medicine, University of Munich
  • , R. PenningAffiliated withDepartment of Forensic Medicine, University of Munich
  • , A. NerlichAffiliated withDepartment of Pathology, Klinikum Bogenhausen
  • , P. RaczAffiliated withDepartment of Pathology, Bernhard Nocht Institute for Tropical Medicine
    • , S. GüntherAffiliated withDepartment of Virology, Clinical Virology Laboratory, Bernhard Nocht Institute for Tropical Medicine

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Abstract

Dengue virus (DENV) is an arthropod-borne virus (family Flaviviridae) causing dengue fever or dengue hemorrhagic fever. Here, we report the first fatal DENV infection imported into Germany. A female traveler was hospitalized with fever and abdominal pain after returning from Ecuador. Due to a suspected acute acalculous cholecystitis, cholecystectomy was performed. After cholecystectomy, severe spontaneous bleeding from the abdominal wound occurred and the patient died. Postmortem analysis of transudate and tissue demonstrated a DENV secondary infection of the patient and a gallbladder wall thickening (GBWT) due to an extensive edema.

Keywords

Dengue virus Germany Dengue hemorrhagic fever Immunohistochemistry