Dear editor,
Kargar et al. recently published the article entitled “Five-year monitoring of considerable changes in tyrosine phosphorylation motifs of the Helicobacter pylori cagA gene in Iran”. The authors concluded that cagA TPMs of H. pylori is undergoing a change from the Western type to the East Asian type in Iran. This conclusion is highly questionable. The recent studies which conducted in Iran strongly concluded that the dominant type of CagA is Western type and there is no East Asian type CagA (EPIYA-D) in Iran (Vaziri et al. 2013; Saberi et al. 2012). This controversy results from the method that Kargar et al. used in their study; they only used PCR method for EPIYA typing which considerably reduced the impact of their study. Based on the well known EPIYA typing protocol (Hatakeyama 2004; Chattopadhyay et al. 2012) the only acceptable methods for CagA EPIYA typing is PCR and sequencing.
References
Chattopadhyay et al. (2012) Distinct repeat motifs at the C-terminal region of cagA of Helicobacter pylori strains isolated from diseased patients and asymptomatic individuals in West Bengal, India. Gut Pathogens 4:4
Hatakeyama M (2004) Oncogenic mechanisms of the Helicobacter pylori cagA protein. Nat Rev Cancer 4(9):688–694
Saberi S, Douraghi M, Azadmanesh K, Shokrgozar MA, Zeraati H, Hosseini ME, Mohagheghi MA, Parsaeian M, Mohammadi M (2012) A potential association between Helicobacter pylori cagA EPIYA and multimerization motifs with cytokeratin 18 cleavage rate during early apoptosis. Helicobacter 17(5):350–357
Vaziri F, Najar Peerayeh S, Alebouyeh M, Molaei M, Maghsoudi N, Zali MR (2013) Determination of Helicobacter pylori cagA EPIYA types in Iranian isolates with different gastroduodenal disorders. Infect Genet Evol 17:101–105
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Alebouyeh, M., Vaziri, F., Peerayeh, S.N. et al. A letter to the editor comment on: five-year monitoring of considerable changes in tyrosine phosphorylation motifs of the Helicobacter pylori cagA gene in Iran. J Appl Genetics 56, 147 (2015). https://doi.org/10.1007/s13353-014-0248-3
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DOI: https://doi.org/10.1007/s13353-014-0248-3